ࡱ> bdax|7 *tbjbjUU 7|7|ZG l4444b b b 8 |,0*N`([[[()))GH),.$ 2 )4/[W[[[/"440"""[h4<("[("8"(p|(B );b b !((000(5"5("4444Supporting Material A New C(1)-Auxiliary for Anomeric Stereocontrol in the Synthesis of a-Sialyl Glycosides. Jannine M. Haberman and David Y. Gin* Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 General Procedures. All reactions were performed in dry modified Schlenk (Kjedahl shape) flasks fitted with a glass stopper or rubber septa under a positive pressure of argon, unless otherwise noted. Air-and moisture-sensitive liquids and solutions were transferred via syringe or stainless steel cannula. Organic solutions were concentrated by rotary evaporation below 35 C at ca. 25 torr. Flash column chromatography was performed employing 230-400 mesh silica gel. Thin-layer chromatography (analytical and preparative) was performed using glass plates pre-coated to a depth of 0.25 mm with 230-400 mesh silica gel impregnated with a fluorescent indicator (254 nm). Materials. Dichloromethane, toluene, and triethylamine were distilled from calcium hydride at 760 Torr. The carbohydrate coupling partners were dried by azeotropic removal of water with toluene in vacuo prior to use. Instrumentation. Infrared (IR) spectra were obtained using a Perkin Elmer Spectrum BX spectrophotometer referenced to a polystyrene standard. Data are presented as frequency of absorption (cm-1). Proton and carbon-13 nuclear magnetic resonance (1H NMR or 13C NMR) spectra were recorded on a Varian 400, a Varian 500 or a Varian Inova 500 NMR spectrometer; chemical shifts are expressed in parts per million (d scale) downfield from tetramethylsilane and are referenced to residual protium in the NMR solvent (CHCl3: d 7.26; C6HD5: d 7.16). Data are presented as follows: chemical shift, multiplicity (s = singlet, d = doublet, t = triplet, bs = broad singlet, m = multiplet and/or multiple resonances), integration, and coupling constants in Hertz (Hz). Representative Glycosylation Procedures  EMBED ChemDraw.Document.5.0  Typical reaction procedure for the installation of the C(1)-XA auxiliary. To a solution of tetra-O-neuraminic acid 27 (309 mg, 0,60 mmol, 1 equiv) and 2-O-methansulfonyl-N,N-dimethylglycolamide (29, 235 mg, 1.3 mmol, 2.2 equiv) in dry DMF (1.9 mL) was added solid Cs2CO3 (213 mg, 0.65 mmol, 1.1 equiv), and the reaction was stirred at 23 C for 6 h. The mixture was diluted with CH2Cl2 (200 mL), and the organic layer was washed with water (2 x 80 mL). The combined aqueous layers were further extracted with CH2Cl2 (100 mL), and the combined organic layers were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (gradient elution: 100% CHCl3(6% MeOH in CHCl3) to afford the neuraminic acid ester 28 (312 mg, 88%).  EMBED ChemDraw.Document.5.0  Typical procedure for sialosyl chloride couplings. To a solution of the sialosyl chloride 14 (56 mg, 0.097 mmol, 1 equiv), methyl 2,3,4-tetra-O-benzyl-a-D-glucopyranoside (17) (90 mg, 0.194 mmol, 2.0 equiv), and Na2HPO4 (55 mg, 0.388 mmol, 4.0 equiv) in toluene (2.3 mL) at  20 C was added solid AgOTf (35 mg, 0.136 mmol, 1.4 equiv). The reaction was stirred at this temperature for 1 h, then at 0 C for 1h. The reaction was diluted with EtOAc (2 mL), and was filtered through celite, washing well with EtOAc. The filtrate was diluted with EtOAc (100 mL) and was washed with saturated aqueous sodium chloride solution (30 mL). The aqueous layer was further extracted with a solution of 2% MeOH in CH2Cl2 (2 x 50 mL), and the combined organic layers were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (6% MeOH in EtOAc) to afford the sialoside 24 (60 mg, 61%) as a 7:1 (a:b) mixture of anomers.  EMBED ChemDraw.Document.5.0  Typical procedure for thiosialoside couplings. To a solution of the ethylthiosialoside 14 (34 mg, 0.057 mmol, 1 equiv), methyl 2,3,4-tetra-O-benzyl-a-D-glucopyranoside (17) (53 mg, 0.053 mmol, 2.0 equiv), and N-iodosuccinimide (38 mg, 0.171 mmol, 3.0 equiv) in CH2Cl2 (1.0 mL) at  50 C was added a catalytic amount of triflic acid (2 mL). The reaction was stirred at this temperature for 2 h and then was diluted with CH2Cl2 (100 mL). The solution was washed sequentially with saturated aqueous sodium bicarbonate solution (30 mL) and saturated aqueous sodium thiosulfate solution (30 mL), and the combined organic layers were dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (45% acetone in toluene) to afford the sialoside 24 (46 mg, 80%) as a 3:1 (a:b) mixture of anomers.  EMBED ChemDraw.Document.5.0  Typical procedure for sialosyl phosphite couplings. To a solution of the sialosyl phosphite 14 (49 mg, 0.072 mmol, 1 equiv) and methyl 2,3,4-tetra-O-benzyl-a-D-glucopyranoside (17) (50 mg, 0.108 mmol, 1.5equiv) in CH2Cl2 (0.7 mL) at  44 C was added a catalytic amount of trimethylsilyl triflate (2 mL). The reaction was stirred at this temperature for 1 h and then was neutralized with the addition of Et3N (20 mL, 0.144 mmol, 2.0 equiv). The reaction was concentrated, and the residue was purified by flash column chromatography (45% acetone in toluene) to afford the sialoside 24 (56 mg, 77%) as a 6:1 (a:b) mixture of anomers.  EMBED ChemDraw.Document.5.0  Typical procedure for base hydrolysis of the C(1)-glycolamide auxiliary. To a solution of sialoside 24 (32 mg, 0.032 mmol, 1 equiv) in MeOH (1 mL) was added an aqueous solution of NaOH (0.5 mL, 1 N NaOH(aq)), and the reaction was stirred at 23 C for 1.5 h. The reaction was acidified with the addition of Amberlyst-15, and the reaction mixture was then filtered and concentrated. The residue was purified by chromatography on LH-20 Sephadex (50% MeOH in CH2Cl2) to afford the corresponding de-acetylated product sialoside as a colorless glassy solid (24 mg, quantitative). Product Characterization  EMBED ChemDraw.Document.5.0  29: Rf = 0.30 (EtOAc); 1H NMR (500 MHz, CDCl3) ( 4.88 (s, 2 H, OCH2), 3.24 (s, 3 H, SO2CH3), 2.96 (s, 3 H, NCH3), 2.95 (s, 3 H, NCH3); 13C NMR (126 MHz, C6D6) ( 165.4, 66.3, 39.4, 36.1, 35.9; FTIR (neat film): 3020, 2940, 1670, 1504, 1419, 1354, 1265, 1174, 1037, 976, 951, 873, 822, 796, 727 cm-1; HRMS (EI) m/z: calcd for C5H11NO4S 181.0409, found 181.0407.  EMBED ChemDraw.Document.5.0  27: Rf = 0.27 (6% acetone in EtOAc); 1H NMR (500 MHz, CDCl3) ( 5.43 (d, 1 H, J = 9.6 Hz, NH), 5.35 (dd, 1 H, J = 4.6, 2.2 Hz, H-7), 5.31 (ddd, 1 H, J = 11.3, 10.1, 5.0 Hz, H-4), 5.01 (ddd, 1 H, J = 6.9, 4.5, 2.4 Hz, H-8), 4.80 (resonance A of ABq, 1 H, J = 14.4 Hz, H-Aa), 4.79 (resonance B of ABq, 1 H, J = 14.4 Hz, H-Ab), 4.53 (dd, 1 H, J = 12.3, 2.5 Hz, H-9a), 4.154.08 (m, 2 H, H-5, H-9b), 4.05 (dd, 1 H, J = 10.6, 2.2 Hz, H-6), 2.95 (s, 3 H, NCH3), 2.94 (s, 3 H, NCH3), 2.56 (dd, 1 H, J = 13.5, 5.0 Hz, H-3e), 2.25 (dd, 1 H, J = 13.5, 11.6 Hz, H-3a), 2.14 (s, 3 H, OAc), 2.13 (s, 3 H, OAc), 2.03 (s, 3 H, OAc), 2.01 (s, 3 H, OAc), 2.00 (s, 3 H, OAc), 1.86 (s, 3 H, NAc); 13C NMR (126 MHz, CDCl3) ( 171. 2, 170.8, 170.6, 170.5, 170.4, 168.4, 166.0, 165.7, 97.3, 73.0, 71.9, 68.4, 68.2, 62.4, 62.3, 49.4, 36.7, 35.9, 35.7, 23.3, 21.1, 21.0, 20.9; FTIR (neat film): 3276, 3065, 2949, 1745, 1667, 1546, 1371, 1231, 1111, 1039 cm-1; HRMS (FAB) m/z: calcd for C25H36N2O15Na 627.2013, found 627.2011.  EMBED ChemDraw.Document.5.0  14 [SEt]: Rf = 0.36 (6% MeOH in EtOAc); 1H NMR (500 MHz, CDCl3) ( 5.54 (d, 1 H, J = 10.2, NH), 5.43 (t, 1 H, J = 2.6 Hz, H-7), 5.28 (ddd, 1 H, J = 11.6, 10.4, 4.9 Hz, H-4), 5.10 (dt, 1 H, J = 8.4, 2.6 Hz, H-8), 4.93 (d, 1 H, J = 14.3 Hz, H-Aa), 4.79 (dd, 1 H, J = 12.4, 2.4 Hz, H-9a), 4.68 (d, 1 H, J = 14.3 Hz, H-Ab), 4.37 (dd, 1 H, J = 10.6, 2.5 Hz, H-6), 4.14 (dd, 1 H, J = 12.4, 8.2 Hz, H-9b), 4.09 (q, 1 H, J = 10.3 Hz, H-5), 2.96 (s, 3 H, NCH3), 2.95 (s, 3 H, NCH3), 2.80 (dq, 1 H, J = 12.0, 7.5 Hz, SCH2), 2.56 (dd, 1 H, J = 13.9, 4.9 Hz, H-3e), 2.52 (dq, 1 H, J = 12.0, 7.5 Hz, SCH2), 2.27 (dd, 1 H, J = 13.9, 11.7 Hz, H-3a), 2.12 (s, 3 H, OAc), 2.06 (s, 3 H, OAc), 1.99 (s, 6 H, OAc), 1.86 (s, 3 H, NAc), 1.21 (t, 3 H, J = 7.5 Hz, CH3); 13C NMR (126 MHz, CDCl3) ( 171.2, 171.1, 170.8, 170.5, 170.4, 167.8, 165.6, 85.3, 73.0, 72.4, 69.5, 68.9, 62.8, 62.3, 49.7, 37.5, 35.9, 35.8, 23.3, 22.8, 21.2, 21.0, 20.9, 14.0; FTIR (neat film): 3618, 3481, 3276, 2938, 1742, 1668, 1548, 1436, 1372, 1229, 1098, 1038, 942 cm-1; HRMS (FAB) m/z: calcd for C25H38N2O13NaS 629.1992, found 629.1991.  EMBED ChemDraw.Document.5.0  14 [Cl]: Rf = 0.34 (6% MeOH in EtOAc); 1H NMR (500 MHz, CDCl3) ( 5.53 (d, 1 H, J = 10.1 Hz, NH), 5.47 (dd, 1 H, J = 6.8, 1.3 Hz, H-7), 5.42 (td, 1 H, J = 10.9, 4.7 Hz, H-4), 5.17 (td, 1 H, J = 6.3, 2.2 Hz, H-8), 4.97 (d, 1 H, J = 14.0 Hz, H-Aa), 4.75 (d, 1 H, J = 14.0, H-Ab), 4.43 (dd, 1 H, J = 12.6, 2.4 Hz, H-9a), 4.37 (dd, 1 H, J = 10.7, 1.3 Hz, H-6), 4.23 (q, 1 H, J = 10.3 Hz, H-5), 4.05 (dd, 1 H, J = 12.5, 5.8 Hz, H-9b), 2.97 (s, 6 H, NCH3), 2.83 (dd, 1 H, J = 13.9, 4.6 Hz, H-3e), 2.43 (dd, 1 H, J = 13.8, 11.4 Hz, H-3a), 2.12 (s, 3 H, OAc), 2.06 (s, 3 H, OAc), 2.03 (s, 6 H, OAc), 1.90 (s, 3 H, NAc); 13C NMR (126 MHz, CDCl3) ( 171.2, 170.9, 170.5, 170.3, 169.9, 165.2, 165.0, 96.6, 74.1, 70.1, 68.9, 67.1, 63.1, 62.3, 48.9, 40.9, 36.0, 35.8, 23.3, 21.2, 21.0; FTIR (neat film): 3281, 3065, 2955, 1749, 1668, 1544, 1436, 1371, 1313, 1226, 1176, 1125, 1097, 1040, 945, 735 cm-1; HRMS (FAB) m/z: calcd for C23H33N2O13NaCl 603.1569, found 603.1569.  EMBED ChemDraw.Document.5.0  14 [OP(OEt)2]: Rf = 0.20 (40% acetone in toluene); 1H NMR (500 MHz, C6D6) ( 5.82 (t, 1 H, J = 2.5 Hz, H-7), 5.73 (dt, 1 H, J = 8.5, 2.5 Hz, H-8), 5.51 (ddd, 1 H, J = 11.5, 10.1, 5.0 Hz, H-4), 5.33 (dd, 1 H, J = 12.3, 2.2 Hz, H-9a), 4.70-4.61 (m, 3 H, H-5, H-6, H-9b), 4.50 (d, 1 H, J = 14.2, Hz, H-Aa), 4.45 (d, 1 H, J = 9.7 Hz, NH), 4.30-4.20 (m, 1 H, OCH2), 4.19 (d, 1 H, J = 14.5 Hz, H-Ab), 4.16-4.02 (m, 3 H, OCH2), 2.91 (dd, 1 H, J = 13.3, 5.1 Hz, H-3e), 2.72 ( ddd, 1 H, J = 13.4, 11.5, 1.7 Hz, H-3a), 2.38 (s, 3 H, NCH3), 1.92 (s, 3 H, Ac), 1.89 (s, 3 H, Ac), 1.75 (s, 3 H, Ac), 1.74 (s, 3 H, NCH3), 1.54 (s, 3 H, Ac), 1.53 (s, 3 H, Ac), 1.37 (t, 3 H, J = 7.1 Hz, CH3), 1.21 (t, 3 H, J = 7.0 Hz, CH3); 13C NMR (126 MHz, C6D6) ( 170.7, 170.3, 170.1, 170.0, 169.3, 167.8, 164.5, 98.6, 73.7, 73.4, 68.8, 68.7, 63.6, 62.3, 58.9, 58.8, 49.2, 39.3, 34.5, 34.1, 22.7, 20.8, 20.4, 20.3, 20.2, 16.9, 16.8; FTIR (neat film): 3488, 3275, 2976, 1744, 1668, 1558, 1371, 1230, 1115, 1038, 944, 733 cm-1; HRMS (FAB) m/z: calcd for C27H43N2O16NaP 705.2248, found 705.2251.  EMBED ChemDraw.Document.5.0  20a: Rf = 0.29 (40% acetone in toluene); 1H NMR (500 MHz, CDCl3) ( 5.63 (d, 1 H, J = 9.2 Hz, NH), 5.38-5.29 (m, 3 H, H-4, H-7, H-8), 4.95 (d, 1 H, J = 14.3 Hz, H-Aa), 4.69 (d, 1 H, J = 14.3 Hz, H-Ab), 4.37 (dd, 1 H, J = 12.3, 2.6 Hz, H-9a), 4.18-4.12 (m, 2 H, H-5, H-6), 4.11 (dd, 1 H, J = 12.4, 5.9 Hz, H-9b), 3.95-3.88 (m, 1 H, H-1), 2.98 (s, 3 H, NCH3), 2.97 (s, 3 H, NCH3), 2.73 (dd, 1 H, J = 12.5, 4.9 Hz, H-3e), 2.14 (s, 3 H, OAc), 2.06 (s, 3 H, OAc), 2.02 (s, 3 H, OAc), 1.99 (s, 3 H, OAc), 1.93-1.85, (m, 5 H, H-3a, NAc, cyH), 1.76-1.56 (m, 3 H, cyH), 1.53-1.45 (m, 1 H, cyH), 1.40-1.07 (m, 5 H, cyH); 13C NMR (126 MHz, CDCl3) ( 171.0, 170.9, 170.6, 170.3, 168.2, 165.6, 98.8, 73.6, 72.5, 70.0, 69.7, 67.8, 62.5, 62.2, 49.1, 38.4, 36.0, 35.9, 34.9, 33.5, 25.6, 24.5, 24.3, 23.4, 21.2, 21.1, 21.0, 20.9; FTIR (neat film): 3474, 3286, 2938, 2860, 1745, 1662, 1557, 1436, 1370, 1227, 1122, 1039, 732 cm-1; HRMS (FAB) m/z: calcd for C29H44N2O14Na 667.2690, found 667.2688. 20b: Rf = 0.33 (40% acetone in toluene); 1H NMR (500 MHz, CDCl3) ( 5.39 (t, 1 H, J = 2.1 Hz, H-7), 5.32-5.22 (m, 2 H, H-4, NH), 5.14(dt, 1 H, J = 8.3, 2.3 Hz, H-8), 4.96 (d, 1 H, J = 14.3 Hz, H-Aa), 4.94(dd, 1 H, J = 12.3, 2.1 Hz, H-9a), 4.65 (d, 1 H, J = 14.2 Hz, H-Ab), 4.15-4.09 (m, 3 H, H-9b, H-6, H-5), 3.85-3.78 (m, 1 H, H-1), 2.97 (s, 3 H, NCH3), 2.96 (s, 3 H, NCH3), 2.55 (dd, 1 H, J = 13.1, 4.8 Hz, H-3e), 2.14 (s, 3 H, OAc), 2.07 (s, 3 H, OAc), 2.05 (dd, 1 H, J = 13.2, 11.7 Hz, H-3a), 2.01 (s, 3 H, OAc), 2.00 (s, 3 H, OAc), 1.90-1.83 (m, 4 H, cyH, NAc), 1.78-1.65 (m, 4 H, cyH), 1.53-1.14 (m, 5 H, cyH); 13C NMR (126 MHz, CDCl3) ( 171.4, 171.3, 170.9, 170.6, 170.4, 167.8, 165.5, 98.6, 73.9, 73.5, 72.6, 69.3, 69.2, 63.2, 62.2, 49.7, 38.5, 35.9, 35.8, 34.4, 33.1, 25.5, 24.4, 24.2, 23.4, 21.3, 21.1, 21.0; FTIR (neat film): 2938, 2860, 1745, 1673, 1548, 1371, 1229, 1118, 1037 cm-1; HRMS (FAB) m/z: calcd for C29H44N2O14Na 667.2690, found 667.2688.  EMBED ChemDraw.Document.5.0  22a: Rf = 0.38 (40% acetone in toluene); 1H NMR (500 MHz, CDCl3) ( 6.12 (d, 1 H, J = 10.0 Hz, NH), 5.375.31 (m, 3 H, H-8, H-7, H-6), 5.26 (ddd, 1 H, J = 11.7, 10.2, 4.8 Hz, H-4), 4.90 (resonance A of ABq, 1 H, J = 14.4 Hz, H-Aa), 4.77 (resonance B of ABq, 1 H, J = 14.4 Hz, H-Ab), 4.42 (dd, 1 H, J = 12.2, 2.2 Hz, H-9a), 4.20 (dd, 1 H, J = 10.6, 1.7 Hz, H-6), 4.15 (dd, 1 H, J = 12.1, 6.1 Hz, H-9b), 4.12 (q, 1 H, J = 10.4 Hz, H-5), 3.82 (m, 1 H, H-3), 2.97 (s, 3 H, NCH3), 2.96 (s, 3 H, NCH3), 2.73 (dd, 1 H, J = 12.6, 4.8 Hz, H-3e), 2.372.23 (m, 2 H, steroidal H), 2.14 (s, 3 H, OAc), 2.03 (s, 3 H, OAc), 2.011.96 (m, 5 H, H-3a, steroidal H), 2.00 (s, 3 H, OAc), 1.87 (s, 3 H, NAc), 1.861.75 (m, 2 H, steroidal H), 1.680.82 (m, 2 H, steroidal H), 0.97 (s, 3 H, H-18), 0.90 (d, 3 H, J = 6.5 Hz, H-20), 0.85 (d, 3 H, J = 6.6 Hz, H-26), 0.84 (d, 3 H, J = 6.6 Hz, H-27), 0.66 (s, 3 H, H-19); 13C NMR (126 MHz, CDCl3) ( 171.0, 170.8, 170.7, 170.5, 170.3, 168.2, 165.7, 140.7, 122.1, 99.2, 75.2, 72.9, 70.6, 70.0, 68.2, 67.8, 62.5, 62.3, 56.9, 56.3, 50.2, 49.1, 42.5, 41.2, 39.9, 38.2, 37.5, 36.6, 36.4, 36.0, 35.9, 32.2, 32.0, 29.6, 28.4, 28.2, 24.5, 24.0, 23.3, 23.0, 22.7, 21.3, 21.2, 21.1, 21.0, 19.4, 18.9, 12.0; FTIR (neat film): 3481, 3283, 2940, 2867, 1745, 1661, 1436, 1370, 1224, 1125, 1040, 736 cm-1; HRMS (FAB) m/z: calcd for C50H78N2O14Na 953.5351, found 953.5352. 22b: Rf = 0.44 (40% acetone in toluene); 1H NMR (500 MHz, CDCl3) ( 5.37 (t, 1 H, J = 2.0 Hz, H-7), 5.30 5.23 (m, 3 H, H-4, H-6 , NH), 5.08 (dt, 1 H, J = 8.0, 2.1 Hz, H-8), 4.92 (d, 1 H, J = 14.2 Hz, H-Aa), 4.86 (dd, 1 H, J = 12.4, 2.1 Hz, H-9a), 4.70 (d, 1 H, J = 14.2 Hz, H-Ab), 4.174.08 (m, 3 H, H-5, H-9b, H-6), 3.59 (m, 1 H, H-3), 2.98 (s, 3 H, NCH3), 2.97 (s, 3 H, NCH3), 2.55 (dd, 1 H, J = 13.2, 5.0 Hz, H-3e), 2.332.20 (m, 2 H, steroidal H), 2.14 (s, 3 H, OAc), 2.10 (dd, 1 H, J = 13.1, 11.8 Hz, H-3a), 2.07 (s, 3 H, OAc), 2.011.92 (m, 2 H, steroidal H), 2.00 (s, 3 H, OAc), 1.99 (s, 3 H, OAc), 1.901.76 (m, 4 H, steroidal H), 1.87 (s, 3 H, NAc), 1.740.83 (m, 20 H, steroidal H), 1.00 (s, 3 H, H-18), 0.91 (d, 3 H, J = 6.4 Hz, H-20), 0.86 (d, 3 H, J = 6.6 Hz, H-26), 0.85 (d, 3 H, J = 6.5 Hz, H-27), 0.67 (s, 3 H, H-19); 13C NMR (126 MHz, CDCl3) ( 171.4, 171.3, 170.8, 170.7, 170.4, 167.6, 165.4, 140.6, 122.3, 98.8, 75.6, 73.7, 72.8, 69.4, 69.1, 63.3, 62.2, 61.5, 57.0, 56.3, 50.3, 49.7, 42.5, 40.0, 39.7, 39.6, 38.4, 37.4, 36.6, 36.4, 36.0, 35.8, 32.1, 32.0, 30.6, 28.4, 28.2, 24.5, 24.0, 23.4, 23.0, 22.8, 21.3, 21.2, 21.1, 21.0, 19.5, 18.9, 12.0; FTIR (neat film): 2939, 2867, 1745, 1668, 1371, 1230, 1119, 1039 cm-1; HRMS (FAB) m/z: calcd for C50H78N2O14Na 953.5351, found 953.5352.  EMBED ChemDraw.Document.5.0  24a: Rf = 0.20 (40% acetone in toluene); 1H NMR (500 MHz, C6D6) ( 7.55-7.51 (m, 2 H, ArH), 7.38-7.34 (m, 2 H, ArH), 7.29-7.21 (m, 4 H, ArH), 7.19-7.00 (m 7 H, ArH), 5.38 (ddd, 1 H, J = 8.2, 5.7, 2.6 Hz, H-8), 5.78 (ddd, 1 H, J = 12.0, 10.1, 4.8 Hz, H-4), 5.64 (dd, 1 H, J = 8.1, 2.1 H, H-7), 5.17 (resonance A of ABq, 1 H, J = 11.1 H, PhCH2), 5.08 (resonance B of ABq, 1 H, J = 11.1 Hz, PhCH2), 5.07 (d, 1 H, J = 10.2 Hz, NH), 5.01 (d, 1 H, J = 11.4 Hz, PhCH2), 4.84 (d, 1 H, J = 11.4 Hz, PhCH2), 4.73 (dd, 1 H, J = 11.0, 4.5 Hz, H-6a), 4.70 (d, 1 H, J = 3.4 Hz, H-1), 4.65 (dd, 1 H, J = 12.6, 2.7 Hz, H-9a), 4.61 (q, 1 H, J = 10.4 Hz, H-5), 4.55 (resonance A of ABq, 1 H, J = 12.1 Hz, PhCH2), 4.53 (dd, 1 H, J = 8.9, 2.2 Hz, H-6), 4.44 (resonance B of ABq, 1 H, J = 12.1 Hz, PhCH2), 4.39 (d, 1 H, J = 14.4 Hz, H-Aa), 4.28 (t, 1 H, J = 9.3 Hz, H-3), 4.13 (dd, 1 H, J = 12.6, 5.9, H-9b), 4.10-4.05 (m, 2 H, H-5, H-6b), 3.96 (t, 1 H, J = 9.4 Hz, H-4), 3.79 (d, 1 H, J = 14.2 Hz, H-Ab), 3.59 (dd, 1 H, J = 9.7, 3.6 Hz, H-2), 3.22 (dd, 1 H, J = 12.5, 4.8 Hz, H-3e), 3.17 (s, 3 H, OCH3), 2.36 (s, 3 H, NCH3), 2.27 (t, 1 H, J = 12.5 Hz, H-3a), 2.04 (s, 3 H, Ac), 1.85 (s, 3 H, Ac), 1.77 (s, 3 H, Ac), 1.73 (s, 3 H, NCH3), 1.63 (s, 3 H, Ac), 1.53(s, 3 H, Ac); 13C NMR (126 MHz, C6D6) ( 171.1, 170.9, 170.6, 170.1, 170.0, 166.8, 165.5, 139.0, 138.9, 138.5, 128.6, 128.5, 128.4, 128.3, 128.2, 128.1, 128.0, 127.9, 127.8, 127.7, 98.8, 98.4, 82.2, 79.7, 77.5, 76.0, 75.0, 73.6, 72.3, 69.9, 69.7, 68.4, 67.0, 63.2, 62.3, 62.1, 55.3, 49.1, 38.4, 36.0, 35.9, 23.4, 21.2, 21.1, 21.0, 20.6; FTIR (neat film): 3488, 3290, 2936, 1747, 1662, 1551, 1454, 1369, 1222, 1123, 1093, 1072, 1044, 741, 699 cm-1; HRMS (FAB) m/z: calcd for C51H64N2O19Na 1031.4001, found 1031.4006. 24b: Rf = 0.28 (40% acetone in toluene); 1H NMR (500 MHz, C6D6) ( 7.55-7.52 (m, 2 H, ArH), 7.36-7.32 (m, 2 H, ArH), 7.24-7.00 (m, 11 H, ArH), 5.92-5.89 (m, 2 H, H-8, H-7), 5.37 (dd, 1 H, J = 12.3, 1.9 Hz, H-9a), 5.63 (td, 1 H, J = 11.2, 5.0 Hz, H-4), 5.33 (d, 1 H, J = 3.5 Hz, H-1), 5.18 (resonance A of ABq, 1 H, J = 11.2 Hz, PhCH2), 5.06 (resonance B of ABq, 1 H, J = 11.2 Hz, PhCH2), 5.02 (resonance A of ABq, 1 H, J = 11.2 Hz, PhCH2), 4.89 (resonance B of ABq, 1 H, J = 11.2 Hz, PhCH2), 4.84 (dd, 1 H, J = 10.3, 2.3 Hz, H-6), 4.73 (dd, 1 H, J = 11.1, 2.3 Hz, H-6a), 4.69-4.61 (m, 3 H, H-9b, H-5, NH), 4.54 (resonance A of ABq, 1 H, J = 12.0 Hz, PhCH2), 4.48 (resonance B of ABq, 1 H, J = 12.0 Hz, PhCH2), 4.42 (dd, 1 H, J = 11.1, 1.9 Hz, H-6b), 4.31 (m, 2 H, H-3, H-Aa), 4.19 (t, 1 H, J = 9.4 Hz, H-4), 4.14 (d, 1 H, J = 14.3 Hz, H-Ab), 4.12 (dt, 1 H, J = 10.1, 1.8 Hz, H-5), 3.90 (dd, 1 H, J = 9.6, 3.5 Hz, H-2), 3.44 (s, 3 H, OCH3), 2.92 (dd, 1 H, J = 13.1, 5.2 Hz, H-3e), 2.38 (s, 3 H, NCH3), 2.36 (dd, 1 H, J = 13.1, 11.5 Hz, H-3a), 1.93 (s, 3 H, Ac), 1.87 (s, 3 H, Ac), 1.74 (s, 3 H, NCH3), 1.71 (s, 3 H, Ac), 1.57 (s, 3 H, Ac), 1.44 (s, 3 H, Ac); 13C NMR (126 MHz, C6D6) ( 171.3, 171.2, 170.8, 170.7, 170.4, 166.8, 165.2, 139.0, 138.9, 138.6, 129.3, 128.6, 128.5, 128.4, 128.2, 128.1, 128.0, 127.9, 127.8, 127.6, 99.7, 98.4, 98.0, 82.3, 80.3, 77.3, 76.0, 75.0, 74.0, 73.3, 71.9, 69.3, 69.2, 69.1, 63.4, 62.5, 62.1, 55.1, 49.5, 37.8, 35.8, 35.7, 23.4, 21.3, 21.1, 21.0, 20.9; FTIR (neat film): 3488, 3290, 2935, 1742, 1674, 1370, 1230, 1164, 1120, 1072, 1041, 743, 699 cm-1; HRMS (FAB) m/z: calcd for C51H64N2O19Na 1031.4001, found 1031.4006.  EMBED ChemDraw.Document.5.0  25a: Rf = 0.14 (20% acetone in CHCl3); 1H NMR (500 MHz, C6D6) ( 7.37-7.30 (m, 4 H, ArH), 7.22-7.16 (m, 5 H, ArH), 7.10-7.05 (m, 1 H, ArH), 5.74 (td, 1 H, J = 7.0, 2.5 Hz, H-8), 5.43 (dd, 1 H, J = 6.9, 2.3 Hz, H-7), 4.88 (ddd, 1 H, J = 16.1, 11.8, 4.7 Hz, H-4), 4.33 (q, 1 H, J = 10.5 Hz, H-5), 4.27 (t, 1 H, J = 6.4 Hz, H-5), 4.22 (dd, 1 H, J = 12.3, 7.0 Hz, H-9b), 4.11 (dd, 1 H, J = 9.8, 2.7 Hz, H-6a), 4.04 (d, 1 H, J = 10.3 Hz, NH), 4.01-3.95 (m, 2 H, H-6b, H-3), 3.38 (s, 3 H, CO2CH3), 3.21 (s, 3 H, OCH3), 2.72 (dd, 1 H, J = 13.1, 4.8 Hz, H-3e), 2.36 (dd, 1 H, J = 12.9, 12.1 Hz, H-3a), 2.03 (s, 3 H, Ac), 1.87 (s, 3 H, Ac), 1.72 (s, 3 H, Ac), 1.57 (s, 3 H, Ac), 1.55 (s, 3 H, Ac); HRMS (FAB) m/z: calcd for C41H53NO18Na 870.3160, found 870.3164. 25b: Rf = 0.10 (20% acetone in CHCl3); 1H NMR (500 MHz, C6D6) ( 7.49-7.44 (m, 2 H, ArH), 7.33-7.29 (m, 2 H, ArH), 7.24-7.19 (m, 2 H, ArH), 7.19-7.14 (m, 2 H, ArH), 7.10-7.04 (m, 2 H, ArH), 5.79 (ddd, 1 H, J = 8.3, 3.1, 2.6 Hz, H-8), 5.71 (dd, 1 H, J = 3.1, 2.8 Hz, H-7), 5.52 (ddd, 1 H, J = 11.4, 10.5, 4.6 Hz, H-4), 5.35 (dd, 1 H, J = 12.4, 2.3 Hz, H-9a), 4.81 (dd, 1 H, J = 10.6, 2.6 Hz, H-6), 4.80 (m, 1 H, H-4), 4.68 (d, 1 H, J = 11.7 Hz, PhCH2), 4.57-4.41 (m, 8 H, H-9b, H-5, PhCH2, NH, H-1, H-2), 4.23 (bs, 1 H, OH), 4.20 (ddd, 1 H, J = 11.0, 3.6, 1.1 Hz, H-3), 4.16 (t, 1 H, J = 4.8 Hz, H-5), 3.98 (dd, 1 H, J = 10.2, 5.0 Hz, H-6a), 3.92 (dd, 1 H, J = 10.1, 4.4 Hz, H-6b), 3.30 (s, 3 H, CO2CH3), 3.16 (s, 3 H, OCH3), 2.78 (dd, 1 H, J = 13.5, 4.8 Hz, H-3e), 1.95 (s, 3 H, Ac), 1.93(dd, 1 H, J = 13.6, 11.8 Hz, H-3a), 1.89 (s, 3 H, Ac), 1.72 (s, 3 H, Ac), 1.59 (s, 3 H, Ac), 1.55 (s, 3 H, Ac); FTIR (neat film): 3481, 3352, 2918, 2846, 1742, 1685, 1540, 1454, 1371, 1229, 1099, 1040, 739, 700 cm-1; HRMS (FAB) m/z: calcd for C41H53NO18Na 870.3160, found 870.3164.  EMBED ChemDraw.Document.5.0  26a: Rf = 0.09 (40% acetone in toluene); 1H NMR (500 MHz, C6D6) ( 7.42-7.37 (m, 2 H, ArH), 7.35-7.31 (m, 2 H, ArH), 7.22-7.16 (m, 4 H, ArH), 7.10-7.05 (m, 2 H, ArH), 5.92 (ddd, 1 H, J = 8.0, 5.6, 2.7 Hz, H-8), 5.72 (dd, 1 H, J = 5.5, 1.9 Hz, H-7), 5.66 (ddd, 1 H, J = 11.5, 10.3, 4.9 Hz, H-4), 5.27 (d, 1 H, J = 10.0 Hz, NH), 5.09 (dd, 1 H, J = 12.1, 2.8 Hz, H-9a), 4.95 (dd, 1 H, J = 9.9, 3.3 Hz, H-6a), 4.84 (d, 1 H, J = 3.6 Hz, H-1), 4.67 (d, 1 H, J = 12.0 Hz, PhCH2), 4.66 (dd, 1 H, J = 10.7, 2.0 Hz, H-6), 4.57 (q, 1 H, J = 10.4 Hz, H-5), 4.50 (d, 1 H, J = 12.1 Hz, PhCH2), 4.49 (resonance A of ABq, 1 H, J = 12.4 Hz, PhCH2), 4.47 (resonance B of ABq, 1 H, J = 12.4 Hz, PhCH2), 4.34 (dd, 1 H, J = 12.2, 7.9 Hz, H-9b), 4.31 (m, 1 H, H-5), 4.30 (d, 1 H, J = 14.2 Hz, H-Aa), 4.25 (d, 1 H, J = 14.1 Hz, H-Ab), 4.20 (dd, 1 H, J = 9.9, 3.5 Hz, H-2), 4.15 (dd, 1 H, J = 9.7, 5.9 Hz, H-6b), 3.99 (dd, 1 H, J = 9.6, 6.3 Hz, H-3), 3.72 (d, 1 H, J = 2.7 Hz, OH), 3.22 (s, 3 H, OCH3), 3.10 (dd, 1 H, J = 12.8, 4.9 Hz, H-3e), 2.51 (t, 1 H, J = 12.3 Hz, H-3a), 2.31 (s, 3 H, NCH3), 1.96 (s, 3 H, Ac), 1.93 (s, 3 H, Ac), 1.71 (s, 3 H, Ac), 1.69 (s, 3 H, NCH3), 1.59 (s, 3 H, Ac), 1.54 (s, 3 H, Ac); FTIR (neat film): 3372, 2922, 2853, 1747, 1654, 1456, 1372, 1224, 1044, 750 cm-1; HRMS (FAB) m/z: calcd for C44H58N2O19Na 941.3531, found 941.3531. 26b: Rf = 0.22 (40% acetone in toluene); 1H NMR (500 MHz, C6D6) ( 7.60-7.57 (m, 2 H, ArH), 7.36-7.28(m, 4 H, ArH), 7.20-7.14 (m, 2 H, ArH), 7.10-7.04 (m, 2 H, ArH), 5.81 (ddd, 1 H, J = 7.2, 5.6, 2.5 Hz, H-8), 5.65 (dd, 1 H, J = 5.6, 2.7 Hz, H-7), 5.50 (ddd, 1 H, J = 11.6, 10.4, 4.6 Hz, H-4), 5.40 (d, 1 H, J = 4.8 Hz, OH), 5.21 (dd, 1 H, J = 12.2, 2.5 Hz, H-9a), 4.97 (d, 1 H, 3.5 Hz, H-1), 4.86 (dd, 1 H, J = 10.7, 2.6 Hz, H-6), 4.68 (dd, 1 H, 9.8, 2.2 Hz, H-3), 4.61 (q, 1 H, J = 10.5 Hz, H-5), 4.57-4.45 (m, 6 H, H-4, H-Aa, PhCH2), 4.39 (dd, 1 H, J = 12.6, 7.3 Hz, H-9b), 4.37 (dd, 1 H, J = 9.9, 3.6 Hz, H-2), 4.29 (m, 1 H, H-5), 4.17 (d, 1 H, J = 14.6 Hz, H-Ab), 4.06 (dd, 1 H, J = 10.0, 6.1 Hz, H-6a), 4.03 (d, 1 H, J = 10.5 Hz, NH), 3.96 (dd, 1 H, J = 10.0, 4.8 Hz, H-6b), 3.31 (s, 3 H, OCH3), 3.06 (dd, 1 H, J = 14.1, 4.7 Hz, H-3e), 2.26 (s, 3 H, NCH3), 2.25 (dd, 1 H, J = 14.1, 11.9 Hz, H-3a), 2.51 (s, 3 H, Ac), 1.95 (s, 3 H, Ac), 1.77 (s, 3 H, Ac), 1.69 (s, 3 H, NCH3), 1.58 (s, 6 H, Ac); FTIR (neat film): 3358, 2924, 2860, 1745, 1654, 1514, 1456, 1372, 1232, 1110, 1040, 750 cm-1; HRMS (FAB) m/z: calcd for C44H58N2O19Na 941.3531, found 941.3531. Submitted: Org. Lett. Haberman and Gin* PAGE 1 SPAGE 1 (0rus 5 7 l m v x  _!#GHX[qs-.01[\]lm j5H*j= UV jU6]H*H*6565OJQJ:CJO(*,.0ds t \]_$a$ ^`st)t>@24z|p!r!!!$$ $:$;$<$_$`$%%%$`a$$a$$a$JNBDJL68:<@XZjlPRVXGHJK !#$46rtvx|6: j|Uj= UV jMUjφ= UVH*OJQJ65 jU jUj9= UVO:.046 !!>!@!B!D!r!t!!!!!!%"B"D"""""####$!$:$<$=$[$\$]$^$`$c$f$g$x$y$$$$$$$$$$$$$$$$$$$$$%% jdH*5\ jUj9w= UV 56:] jUj_= UV jUH*5OJQJ6M%%%%%%%%%%%%%%%%%%%%%&&*&+&-&.&=&>&]&^&&&&&&& '!'C'D'''''''''(((((((()))))))))))))))))))* * *'*(*<*=*?* jUjw= UV jd5\ j?Uj]w= UV jUH*6H*S%%%)))))B.C.D.g.h.%2&2'2J2K26662747m;AAAAA$`a$$a$?*@*N*P*l*m*******++*+++M+N+t+u+++++++++++,,7,8,L,M,_,`,,,,,,,,----- . ..... .!.".$.D.E.c.d.e.f.h.p.s.t............/%/'/K/L/m/n//5\ jUjw= UV jUH*H*6 jdX////////'0(0:0;0b0c0000000111111122222%2'2(2F2G2H2I2K2V2W2Y2\2]22222222222222233f3g33333333334)4*4Y4Z444444445 5H*\5\5 jUj5x= UV jU\ jdH*H*6T5 5555$5%5&5'5)5*5Z6^6x6~6666666666666*7,7.7074787:7@7B7D777777777.8/8P8Q8s8t8888899%9&99:::::';);6;9;F;H;I;K;L;M;N;P;m;<<< < <P<R<z<|< 5OJQJ j Ujx= UV jU56 jdH*H*V|<<<<<==d=f=====^>_>s>t>>>>>i?k?????@@AA6A:AZ^Z_ZZZZZZZZZ[["[#[s[t[[[[[[[[[W]Y]f]i]v]x]y]{]|]}]~]]]]]]]] jaUj-{= UV jU6 jdH*H*Z]]^^^ ^ ^D^F^L^N^p^r^t^v^z^|^2_4_~____``3`4`U`V`}`~````````aaa:a;aaaaaaaaaabbb b bDbFbLbNbpbrbtbvbzb|bccccddKdLdsdtdddddddeeIeJekeleeeeeee6 jdH*H* 5OJQJ5^eeeee#f$ffffg gggggg3g5g6gTgUgVgWgXghhh h hPhRhthvhxhzh~hhjiliiijj3j4jTjUj|j}jjjjjjjjjkk/k0k@kAkckdktkukkkkkkkkkllnBnnnnnnnnnnnnooooo"p#pIpJpupvppppp#q$qYqZqlqmqqqqqqqrr;r*CJ jd5\ 5OJQJ5H*6H*Wstttt t t t ttttttttt*t0JmHnHu0J j0JU :>*CJ t tttttttt t!t"t#t$t%t&t't(t)t*t&`#$/ =!"#$8%Ddp<  C A20e+Ê D`!e+Êe7 x]|[$dOGB,F A lDP2\x@TZZT{QjVkA[ցsr'T~}ϻ"U !R"Csmxҵ:bLBIcAG ym [ ʀ !m8#tC\}#b`OL&ͯ!"S \ yzMaHެF=nL7֘Ūff$#w44C+kQE6EafMx4Cy>1p5m͇*qMdQnP!._GZKFgӆ'bsmiN͵uzlm_tblAKK~/z!0>:x GWκU0X?#\ru-(]7#:c͏u\úUkp5sZ$rΜ\>-RWT:A,3'&H]ujXu5jpՑFJE<GJC]|ȅK+ϲrQ_o(:mpJrk_wltCٱicm2wvl؂c&͏jbLISAއϷkqעƷPZxLǷ"tEfe(SנKV+mߥS>^w γ2oM-42+}L8ik1WVR:֊p ˍ0[䳩K5– _OG|C> 7#3#|06W=me#lIJl8^P %)a:6ğ m;ζJanKRdZėa>Y\nKRlRR0\vv+ۺ>$%V8ކxˡ'0܌Q:C8ކxjDn< "&"~ShAu̍%)a:6Ŀ]m w"lIJl8^0z,覅ےu"oDBs7tY-|1}soU!$qqըkc᥈%lǗ#qތxLXGŚJ!X[^=<I xa;//֑xipaǒ3n5cɺx~!+)a..{A3?4A=[ᲒBx㭰:YQ-NZHQ-JYTՈO bG١%í:C{zܯ{rwGx5#Z^4>>Z[ ϱ?cp|`U;^9C8F r`nGRԫ??C8)rϒ%Dv]bJub][KŇ-3l!|,£>^C9g>x'7^sM߾) 5%iYװhZ =(U=E&g0Paʻ4as;qJ8Ty "-%cZ,.gt! 99Aڇ֫J?.~ x3 ̒J 5 .ICd7p)Oղm)Ҝ]uB|A)P(30 FtHY-r> Xx!v("i,ғEL=+˝m1o~tڶdh"9{3!]H(iʋإ˕]^al /bRƿ/c"/ (LF=wew+i쁌ˠmWc_?#'x-B8y#KW(+ٛ(ɻGpz W0~%2+Cs݂s;=If!~x#(Y(t;L<7K.|w^ .ݨD8ps71~=70~3? ?fo?`LmdA;Ôgy~5eg|jX2u ZF~d%ӷ7)<ەL3#)v[m2ݗcd}\yNv5Q-{'F,ѶbzT=ɮ"O#6D[jS7tayx ˝%IpZt)nĊ+.,f5 .*B)In-a6.ӫHnSkcLmsVe`b,wK%mj.,gN`5]X WxEѼ:|cA^r'+NwPzJ︇~v.{_0~_۷>Xa+8A5IJ%N 1LP1Ҍ"z|(q ^tྫU)c:"xV)=Ϟ^)Sjʎe!ܩgĜ'Wfғ/sqlQ}8v&l<#|᯹<| S N0`f,cơm`fŒ8̷ tٓGQP9G9Cd!f|'3U/c8 19Fc:5tmMa ocJg/~dꉐm=yc18O18U _q~gXOUMe|pT9޷ +m8:i2gT>.QyQI۟89g8g?vXM n>?ݭa瑾kfa8̝'K| YzIIJv7(<{r/q{]5w1Jrs;հf{}<㓏d[f.?܆m`?'o({S{[I>mM  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXZ[\]^_`cf'whijklmnopqrstuvz{|}~Root EntryP FPeTData YDWordDocumentOObjectPoolRöP_1034858156!mA. ööOle CompObj~ObjInfo  !"#$%&'(),/0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcfijklmnopqrstuvwxyz{|}~ !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qCONTENTSg_1033732665 !mA. ԶԶOle CompObj ~VjCD0100ChemDraw 5.0figs supp mat.cdx.._M> ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialD C@ M01  J01  M  CM01 #! F&  `OMIDZI            F 01   =01  M@M  6Q O`AcO949EF+GHIN JNIKFGLGHMGI  MM `AcNHO KPOP+QRS+X TXSUPQVQRWQS  FO M`OAcMIDIYZ[+\]b ^bZ_Z\`[\a\]  3R P`OAcs616cde+fgl hldidfjefkfg  sSP N`OAc3VQVmno+pqv rvnsnptopupq  H!  "  M9M `OAc <7<wxy+z{ |x}xz~yzz{# !" R  `OUP3U   C"  `O@F@ A Fs%   H+  C@4  9@4  `OZ<17s2<6  H= `NMe2K:F;MK++  U S3DPV TfM K01\[jW UJfU01\]pX VfMM_Y W3Dd01^_r{Z XFsZu s `OIWDXI&][ YUV\ ZVW] [WX^ \XY_ ]YZ` ^UZa _FF01lbdb `Uac a= K01ndfd bace cM@&Af dceg e6Fv t`AcO9I4<9I+ h fegi gfMf@t r`AcNH&P&CK2PB++ j hVik iF3;x v`OAcI3>D0I=+ l jakm kM4Ps q`OAc 7ZN2O7[+ n lcmo mSPw u`AcOVSQEVR+ p nWoq o9dy w`OAcZ<Mb7c<o+ r pYqz xIm| z`CO2HKskGlM}+ { yYz} {< `MeSO3@?3:A~ |A }}~ ~< ~ A@ `NMe2MD?F++   f2  `O&5f0f53      JJ sS 0  Cs2CO33VQW 27]_X_]f 28]X]C A29616ObjInfo CONTENTSy1_1033733839 !mA. ۶۶Ole :VjCD0100ChemDraw 5.0figs supp mat.cdx|+h> ##  B5 $$$$x ff  `  xdLT4g(dd'`Arial @L ڤG01 ڡZQ01 ڤ \ @`01  ! MV  `O &T@T@Y             MB01       G01     <  f?$ "`AcOMfB5B+   ڤ< `AcNH?.?++   M@7"  `OAc @:-:+    sG% #`OAc3EER+   3L# !`OAcOAN+   i    `& $`Cl͓^_d!  ' %i6 4 `OZgZgk( &') '@@r5 3 `Oo3p3t* ()+ ){, *)+- +@. ,+-/ -Z4 2 `O@MM0 .-/1 /3 1`NMe2@@++ 2 0-17 501=BJ8 601=>H9 73@01?>F: 801?@D; 9T R `OM&< :&= ;78> <89? =9:@ >:;A ?;<B @7<C AڜR P`OMeM+ D B:CE CMQ O`BnOM++++++ F D9EG EsP N`OBns+ + + + + +           H F8GI GO M`OBnZ+++++ +* !*" #$%&'() J H7IK I̓L J<KM K̓S Q`OH+N LKMU S    +W U@V T8     AgOTf, Na2HPO4,-/./0 1 2 3456-.7-38/3934:35;/0</1=/2Z X17[ Y14 [Cl]RRf>\ Z3] [f01cbq^ \$01cdw_ ]fM.` ^3301efya _ڜM)| z `O&͚&'͟+b `\]c a]^d b^_e c_`f d`ag e\ah fڜ@01siki g\hj h01ukmk ihjl jsm kjln l} {`AcOs?@+ABCH DHCE@AFABGACo mlnp nff{ y`AcNH&&IJ+KLM+R NRMOJKPKLQKMq o]pr pڜ3  }`OAc3  STU+VW\ X\TYTVZUV[VWs qhrt rz x`OAcMZ$]^_+`af bf^c^`d_`e`au sjtv tͩ&~ |`AcO&"!gh+ijkp lpkmhinijoikw u^vx v͏3y w`x ~@<  `O :3f:3> ` @B01 @MG01 Q01 @Z01 U  `O@ SsfSsW  K       ZZ `OMe XXfqrs+v tvrurs  s V `BnO3 YKXwxy+z+{+|+}+~+ xyyzz{{||}x}x~~  @3= `OBn3@2?++++++    8 `OBnͪ;.;++++++   MF    +  `O((f- x <  `O :f:> x ͏ME   N   N  `OfK~KfP  ͏V `NMe2TUe++   24"") !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qCompObj ~ObjInfo CONTENTS1_1033734670!mA. ඩඩVjCD0100ChemDraw 5.0figs supp mat.cdx- k> ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialM KON LI01TSbO MS01TUhP NM^Q O c01VWnlR PXj h `OMfVV@[S QMNT RNOU SOPV TPQW UQRX VMRY WD01dZ\Z XMY[ YI01f\^\ ZY[] [M ?^ \[]_ ]Aq o`AcOD7D+ ` ^]_a _ ?i g`AcNH A1 A+  +       b `Nac a9o m`OAcM</<+ d bYce cIr p`OAcs@GHT+# # !"f d[eg es ZNp n`OAc3ZQ DQ$%&+'(- )-%*%'+&','(h fOgk ikl jQkm kM cs q`SEt `al./0+1+5 25/3/1401n lQmt r k  `O@i inu sktv tt  `O@rsZrsvw ukvx v}y wvxz x{ yxz| z  `OZڃZ} {z|~ | ~`NMe2678+9+= :=7;78<79 }z~> 01 01 01  01    `Of Mf         `OMeZ?@A+D BD@C@A   `BnOsEFG+H+I+J+K+L+MW NWMOFGPGHQHIRIJSJKTFKUFLVLM   `OBn@XYZ[+\+]+^+_+`+j ajYbY`cZ[d[\e\]f]^g^_hZ_iZ`  M `OBn klmn+o+p+q+r+s+} t}lulsvmnwnoxopypqzqr{mr|ms  Z  @ `OHM@+      @@@@~ ڻ NIS, TfOH@   + 17@ 14 [SEt]@TUm s! 01 &01 0 s 601 +  `O ) f) -       01  01  @   `AcO +    `AcNHff++   s  `OAcs+    `OAc&+    f! `AcOf$ $+    6  >  `O@M<s<s&A  D01 I01  @S01 \01 W  `O MUU &Z M &N       \ `OMeZMZ[i+   MX `BnOsM[N[++++++   s? `OBn@sB5B++++++   M : `OBn =0 =++++++   H   M-  `O*&+/  >  `OM<<&A   G  MP  MP  `OM&NR   Y `NMe2VWg++   24@@$$,Ole  CompObj ~ObjInfoCONTENTS93VjCD0100ChemDraw 5.0figs supp mat.cdx<-}k> ##  B5 $$$$x ff  `  xdLT4g(dd'`Arial ZO ZdI01 ZaS01 ZdM^ Z c01 ]X  `O`fV[V`@[       ]D01     UI01        W ?         NA `AcOPDL7QD+       Zd ? `AcNHgAb1gA++   ]9 `OAc`<[/`<+   JI  `OAcM@GHHMT+    jZN `OAcsmZQhDmQ+   `k  P c! `OP(OEt)2MS`NaU~++++  "  jk1 / `Ol@i hi mn# !"$ "Zt0 . `O]rXZr]v% #$& $`}' %$&( &Z) '&(* (P/ - `OSNڃSZ+ )(*, *`. ,`NMe2bZ^d++ - +(,2 0G018=E3 1O0189C4 23M01:9A5 3O01:;?6 4G O M `OIDIf7 5If8 6239 734: 845; 956< :67= ;27> <YM K`OMe\W\+ ? =5>@ >UL J`BnOXSX++++++      A ?4@B @OK I`OBnRMR++++++" " !C A3BD BIJ H`OBnMLGL#$%&+'+(+)+*+++5 ,5$-$+.%&/&'0'(1()2)*3%*4%+E C2DF D@ZG E7FH F@@N L`OHC@>C+I GFHP N    b@b@6R P@nZQ OTMSOTfqflq789+:+;+<=> ? @ ABCD89E8:F8;G8<H<AI=AJABKACL=>M=?N=@S Q17\W\T R7   14 [OP(OEt)2]z@TuU{OU SY!V Tb01\[jW U`&01\]pX Vb0Y WY 601^_rzZ XZ\+u s `O_ )MZf)M_-[ YUV\ ZVW] [WX^ \XY_ ]YZ` ^UZa _Z\01lbdb `Uac a&S01ndfd bace cU@f dceg e Lv t`AcONJ OPQ+RSTY UYTVQRWRSXRTh fegi gbt r`AcNHef`eZ[+\]^+c _c^`[\a\]b\^j hVik iZ\s x v`OAc_sZ_def+ghm imejegkfglghl jakm k Is q`OAcKGL&nop+qrw swotoqupqvqrn lcmo mMif!w u`AcO lf$gl$xy+z{| }|~yzz{z|p nWoq oMO 6r pYqy w^>  `OaM<\<a&Az xYy{ yeD01| zmI01} {3k@S01~ |m\01 }eW  `OgMUbUg&Z ~g&N {| |} }~ ~  { w\ `OMezMZu[zi+  ~ sMX `BnOvM[qNv[++++++  } ms? `OBnpsBk5pB++++++  | g: `OBnMj=e0j=++++++  { ^H  y @JM-  `OM*3H&+3M/ q @J>  `OMM<3H<3M&A q MOG  @JMP  &@MP  `OBM>&NCR  MO Y `NMe2 RVMWSg++   24y@$t$y,o_2uuZn' NVi' K9mrZLS}YzW{J7+<)c#x2?d|?w(I{H LOpdX# Ɗ^vꓸe|s|)L}&?Ur0y +'9 0i2tr4<}4C$!v^e`y6L7 Q԰қLkpجJ-OE'53Yi#/ƑmlSf3ٙ,ԙK14LkfV6{jvbpaW vpl'6_?:lNÀrg7zy뇸tqH+688hfVNl򪩂hs W:I\El׃c.fcudC3/-oΦZ/:gz :O1p 9c;j%Not'13խkbC>&C^0c٧Y4)(%}teCׄ&k9Q>-&Lc}:k9j \ҦY gzYJa2NG54nX Q["WD,!0"\._S6&k9'i:/O02뽌3Io:rX`n/_dw{6]|bMOMNh>oG1fKL[bs)_DU/iEc)_B=hs!5 -YU㭋-(1l7Ѽ/ES8>!FLٳg+foK벓<``">XBo7 E 9dgsJ)xAT<硞4< 騷|Éxwԗxs)5t1SBԔX)yx^54,O};OKQsW{*CB1;LH/C>y.s=<\@~.KEy ^z'޾ ?A,@~xS,y y(I σYn 3 pJMq},ՐI%KǵV)3lʡ ːNwY_a>ez?eȕju!Y3˟B#Ų/}X ̹;{873~Bsr$}ZrE=XUVM}c(Cl-q}șnm"|sʫy{ #yIo_[r߲{x?轫`1ئ0,,#z,m|Nzg)I9i%ֳbsc>}'E&a0m };w_׫nn(oxwZS=.jH`N綱qZ u䶱UcV}0v3wO71%߲JiĻ;oIdn)֯Ӊ`~cw۬#C)ﮀ8yMl^rr@?21eQ(^ 蝕쳿dn.!9'2C2ϣv{7b&,fqғb##UMVK#֋Pl7%b)̹7*HuM镫8yο*6w,4W5*cbv2 Sk7t iS\؝tj~]} q’poEI®IAju6>H8X]"h9!y _էT`XLU doYW +q?giO5ʸa,.Dqa&YZsqo׊(h$:7?nHr6 [t]:6gIFZr[ ,!j 1@UNQnp)}^ (e3n=E\'G "_w؉(=N/cJPnI"`؁fGERoYJмnt^5K )Ag"& {dS{j 24& s44'ReՈ2;&2QO(O&?;%K?ꜟT~TL~}DPM~##[Nb -I_L~4 &qc}ZBdiK=I AOLFGD7u2ʱ@N]"F eIFxua- ^S\?1V(N@,99Ɛ m@CQuD1GUYDP=?^-UXo!؅Ng5+}$֊:&UOْ8c_ne|"|$IBT'&"='i$C։ֈ^H-S}jsh5n.A4ԜLŋx$["lTeJ,k@)(F$}ȟlgGʪwa礢v2S4Q0b&81)ekZ|;DM bXXbwFZ~Uίw^(LzSjj܁DmSݱnDSxqOYYyyYU2uCT-ՖAkv%Z#W΃GQ~pDJţkb*k$&v(BeeY;~72W64k9],~&^:GJ3|tM4Ӭ7`#(R0bŷ[Rk/Rm`r &r>Kn)'>Wl&31Pku.av5h"[4鵣;_`+Ղ]@ ;[ILgvs <#=$Ml\}q)4mjBXwhKJ<e t*Xia,rR,.z֛+Tckgv!'K8Wgv K*k娧/a;S3RƯ]ڈz6~vQp۩ ;!릔0{rC@SQϋV]ҧ(7H2.)c!GƱ\MG+ @#I^osUrXt'J=RCn'ƒ<]$.~V g.@sw:Qn W;~=lb]2ƩJ {CipzB=ac>N|"+ؙqF(nQp&L"{ԾNW"]J BoӋJ%v%POzKI&8&e"$}tp'EW6s*V[KO'lV,:+짣}Ί LΙ-􉃿o 3&' MYEIeZwZpZmAk%I _?q5%ơW8oĊ/Dd <  C A2w.$زFEԉb=VS.`!K.$زFEԉb=V$n P= .x} |EuIȝp Ȅ$3pGFQ9DE@U?YueEUucU?W_OwuzlYݯ^UWL4Ϙ68cРg?ouH9c?.yi 9Ryh] &*5w;d҆.o5<zpIsjh*bkr3Mĭ`pn*:إ;4iգ"oZ#)vbfƪr\֮ՈɈ" 58ʼn[< عz4JORɘ#>gk"s|+1Szl ){S6R)ޭc3 9k16F? xg}}.VeB5s̷JZ?HvsaS~c T[+w[Hc3zKVwZȍ*+6ʼn_l"kj=6WoZ?CZ'}64V[M.EÏ#Gc<9{^^=̟ל^~Egۼ]p$/=x uvN=̃d8Rڅлڅffڎͨ%t~lF1ͨfڌm{tΏb 8Cٝb+Os+!MA\OAX+=+G y{]!ub۰[tseX6c͕G nJ,wwZw!_vϡ 1h.t_u-Gך#⎵c3lZ͘[9s#&Ef;WNHp8SHҕbNp֕&DΐJ(YW("]>x;C/pT?wfj8?y9HX^k17w?oBFZy.<6]Co1V O+4O*=b78K큦 ד֩⩘Q< ?QL{<3BHTУ$(کKڅY/_bb33flFͥ۔hUV$zlFmzbRVO un̴Oڎ${׿k;ZO 9S!kU#|9YIj3G,?ML3-0Zス'b. CaKRj2g| sg䏁}Y$k4_CVRd \7;CVR/E|  nsm8$^s>eys%Է!+)Nx .,5\sG g[RS/sƫ}TI[U [d|p9-'Fİ%)N*g;zG~4-Iq]RwΙb~ 4;9S_hk뀗;?8mC4g/]5G`uQ:OdFu՟) x9#.01w q4Mt7O ?<ԭSeVc]CbfWHnqWjM}gQ+ cK.9x6p8frkvrh[߷o&M8F㢖98m8C,f.<ܲcyԘό!xy֘/.b604XeA鑳nP'[)+il2gp0ZD^I!gY|7!34\p9E$' "z>^_7@8"SK.b9.HB+I~ՇYп q'H>IDVc!S_~&IDܺH^`HC7IJApy,(t~ހ;Gj` M gݑxz<=""F1!dt^&LJTQD կxt%5`kc_3rS'ZLH" 0 ;ԒKR, H"*L I0In^(B:(Dr$Jdrd |(P&*PPQy5v ӱE \`Drrra%CyrRAȃJQdCD( ea ~piy)٨ZrFYHAdH%ӉjHȹ'Ҁp+zl{nSX=oǕ#/P2uZ^;d=AX$qB6qK2(i:Lc*ה5*"Zy":{d7K5L3hY%MWR%m/P0 g  ?Is?oIΑE L13lb38o=N"H ›9e`bJZ-Ć[ZzYI+J^%o^Sx$u OLWlJk5Wbϲ_[/ܭGz: f79n* ,=pb[h?+|\zGP)=O6goN ֧e+m=1Dz"rPH1QCt}ڊkO%p&(.e0SS71dJYt )kИ\hE {@=nw ̦ؑp,eӚԴ|(zB+r 2WjBW;pX}Bzs ڒ֊6dQۘ]ǮDDirmHu j;w=ʵ#$K(t!S_h@~Fa) O,< NN29N\]uqs)Ep 6/ ҃D"`8PE$ҝW؀`HH/aZ9*җHoirUŨjXL8f#$ eCjz?'Jou;eI0=v'%#A˷liz^ӗxHED-$jR{QڗYCy-&j!-moĮD^X27{nAfp=^4n@KS2RS|E#KˈG)*(/"jװi*y a5[Ujߏ,PGr'pAiDnУUDs_o(H}uNiKi}~֏J]5qg(AH)-D£[qGM<Ϸ$dw/d%}O܆@ fQ 7"s֙(p‡,U`Q%[M阾"pkxFvWӝӬ]|J˯J+YK"C)JPG{Dp顽Oēl2dSG<~M%OxA6[dmxP3` ugfN.6`Q}P/="(J#T [`x(L,,*YOiWZ VCRR(A)AYƄg" لu茦Sxl3^A9'$ۂ7tmi!ɶ!K \Qu^'awIp?')Qɕ\)QKL9&gKަv6BXʻb^)F#CI)(K}RFc ASz`iN[qyksI_J G M*u/X<!|b(V0mhĎq\){ḟbw{&o㚙a"kG&2:!4^߁(JhY7]QAw(Ʈ6NT`ûމcIhHrrcC#R |*K*<⼜j957"Id'qhQMNv2M@M$溺O$~E\PlaN9C JN"50f NYc91N&I=K91')Xa٤' SI<::S'RLW8< ˛O3-$2UQ8 4]j, e- gtT8 :m\:#2f,",s' *¯<]`q'M.8:L.8\)|װf\ДW VePDIH i)&_ϣ\nƘR\kqND | SCt%o5pA~ k#y0yJb+ɛ@ɛT*ɛDAWR唌 @d)O |b-/5<8v !yW,a/DH1Ƕ[D%؊a:jYI"+L+G"y3"kX6^=1 y1,\anTjR>3Op!*ZN^AWWr+Zb\Gk,+kg%'H]IUD@uH]EDHjJ&n{fįُAvF!ȩ#`OqU2˅4.h^@\YfwMnQzD??|0ELs04-Qn]TZKUJj5J*PR-#|1Kˉg \A++d%+g)ɮ$|)W9ȮvɮWuV BE[iSo( uwMNay[zy$R+JbҵfEimUZ۔Q)픠)A)qm |:i'l$M$MovMθx~px-${~AnoI~R;;+v:sv^weʭ&&ހԈBu᧬z}`({+ƚD^7˩VGjZXL.L.'Mp}y7w R ח٧Oo!~sQ\RY=Hz-$wX6^#$wn%!A9 ~G`+aN8H0ð? XPM>R(lN5HaKGGϭm\fIxe|Vr&βhX&pb_>򀲚:V&4hAs?  Ȇ ;(۔d}/qcMH|X~&~$u29PTҿ]̮bmtPc1KfVOaYXO+xP B~#ȍ_|W $r {3@[>ߋ \a$x>9S.ec NpGW P -ΥMO~$?|\s En$`w$8asIr4Ib  ^:I}E rmtLcop?78AnhJ Kt8.X.c8!L@Aw| Mvw-O?&;&o3 HOFU RSs|Ǒon(]h.ϔZ_2K> ޔ%/˂3s/˃7Օӯ|-`,ʄoHʖo ޔ)l)owl \%C̐wnvnʒ73x>-oOjɃѩy`Hisiq,, s$pN88x8Ӏ\,Л%x]ЗpNs#|1ՁvkД/'8\>4tzLdYg>Xzed:^EW@&ly x`b4E&)'ؙȚ`gkZ ւׂy [iXk8Oy&ܶp z\ˁ9/}p^puby@_Xguf]օuZ֕u:wF [ Y7; s|e}|h̅|2W烐\^ X!o3fNJpŻ]oO0k9HD^8%L|M״Dll)Տ}kHF?k~Zt[Ҟlws;"wW|N{Şd W>BcHpy ~9vx[B]<{GMt`Ap1~eӻ[Lu^[,)9M2u!m㲃[cξ621dLz{>0. ~na/ 򈷓o~f$2ѓI0Ie}Ie~W=#Iw pқH`a1gx['=F>x4<= 'w( Vvy߷vL yq ߫J- 'bm-Ox7=/ ,xWuT1Bc ɰg;=Gweeʘ|K}ߕF,]b,IKHuʱO_W]`aꏨe[K/mۙSL.NO"}/p[Zd|+pw?06=CfyUyfL ݲ?KGM~Iϐ͇׳\Ȼxd3zwwdaI~;86F} ޛݟcR4x3wS(glVdG$8[߀R}ܦw^6>oo, [Ꞗ_D^~+J8L#Jp_(,_=]6EgSdy'FR =s~όVNšېnh~[š XOwӿG&ul2\ww]o=!XtXEE"Xfd``R+U\E62 )ʐ?/X ۚ=$/>dJh V m+yJ 4*YV*\Mj}W f),`YRZO'L+G̈́t}EV*;OT7GZB)@zfw6Qu<˦.77k*M5'ѨXlLbFؒa3P6հʽF]Cnj[cx3biƞ+:ӛ?*M)mtYyͰalFT[ی:e5J0l,V*̜UZ|HQ1|~P\), D,`MlۚlX2CF)ATQE}sR46ؿrǧٗ&UnEѵs^'$C=ѐz;eʭ_D:j֢J}_KYzgka-kgܶc.V9,)sշ S3MO<bZ;suκ0KǤw`ݘ5q㦯=VDy]`G! fI,Lj,j\*c- RW6f_oyM]m$ Ƽg=LMbG;fMNX`ZL%yZiV?0KeIYK3lf{ %6 ѥՊ%O߷ʱ۱^ـG8ʄf&yHMj&LVfILfR:m0w-cN}NBea֍}D3x2IFgY_Fė{Vy=bw>c=@כEYu>mFz?qfz8K+T/fis{cZbq 5Tyu\!Z^5GyCR\zT{2zޗ{vʥo%8̗:KQٙF?Ky!tNkcIy, Y8s1lYu90)9)w-Պ^ 5VduW\Fgl*: r&XJT%. Cм>w, ҝYeZaVbb۾yi^+sĘ pgeEXl1Hj:HݖH6\ΏF=.XF2l^l [W6忉6Y5n3L&J3soaTʕYzbh GuU>yҌ-=MPv:4tEqkebe*pQ+<0I:+ slΫ gk=U%0X|[eaxF{BeUT)HjuhnLg3.3 VYVgLQ=Y}c &dl-/V7i3|fMuQ̅*_JJ6X0KMͥM PP/ӲI Z:Y Kؗu|uW`(LgZ1s/aɺ+XYVf,۝R7r?];\,lRoF%^cؖh"0PcamPW 5lńŴ׫j]&9ȩѲ,zjMW޲=YKMZ8qւ)p}RmNr6`)QXT0]\VؿhxC999;v͑xǶB@}l&_^fUы}' у.OoΆ|7>M:gAd|)=]$[N$|-%lQ$YPA_*5AkBHq̲hrSXEQlŷq~ 6P(ؕ#BS>ZN2WaNekxV>re *4Y:wjKW$hs5l !,Iu=񵅢s[Gy$YΑj̲+|Soe(͏X]h&f[<"kOl7G@Pº5D=Bw|R =7SJMh̅L=wCmHcZ_ nX3NUR=KWb ia%vHU+@o5VqBߥ-!yk\=(EJ{}`$#-LK|HޡJ):>u|tGJE2MV+*Je,׶iNl5JOHRiR%ҋRFMĺ)2Ǒ̃bԦĽ)-*JQ[%cf} oJJzQ[oWh5#!LeHG@ˆRMB\ѿMe^ߋP>Xm&2v{~k4#HiwКU&_[CLRmz`4sK|2D290v]>+vBᗒ|HB^,Azrm.pmetˣuR?=xQel8PI z4ʵ;L]JcޕˊE+߭i-x<אn\Uz y'гXRXc%TuDs0EɸCc12Y]Y0`ǡ7 } HV\1}gKxQ}Cr5^'*y<$b"HYXQc[^9YۢT Շ/&Ʃ)z&ޙx=umbZVa]GAF׳_): cX2fd~S?irU,EOP]\­~NeJɯS,"6P,14OYM4[i̷-BK=`tIE+=><uUo.`E471eD 3jݨ #V,Eje~ ,HbdBmVyH#) 6I5Mǖ+mCqbEmk,cưyHJԃR<|mHl" RV!Fy Flc8uBY> |_2kjUsZ %.~ۨ!___q|hh*s+&)?Wu5f^V'SVlSda\ȿq//Dd <  C A2u.JNC!&Z{Q. N`!I.JNC!&Z{6YP= .x}UU=I= 30aA280FrPVQȢ"*v k]E]X֜Vo "ʮ9unMˎ]}ߓ95R$qˆOOB I88} ]&&蟆 ~OA1_X]?2Y SgK~ zI,g7KS!Isj>kS_EI 5lB@Yjկsm2@kGھ鞾QM 蟳"o/p}[4^ TtqmV߈Aֱȍ{u3ֺo>}l^e#=׺oָjp-殳iI7غܽ>] 1^/a2%S,](}uVֈ7zG7u%봞SWGh#u=WSj|D_3u}|MG,xellxM_Pk56u[;߱Ѳ2Mߒi-?զoIFfZV۾Yݭ}AYYgm[Z]뾝wWSmvJ=jfk7Scqu=Z+}}[sox3f@i>=O7f,zP@B/:?m\?zL{{􎺅赓gCmMko}gv~yZX;?Hǟj7+^Y~Hgl_jݬj xMDGS#D xX5n2L^Τ\kEO]ua>|?m~0m36ݲ+ k?d+2gI#ë5ig)${nT7oГֺ5*BO2_b?R?O؃zFП?k׏mk?Kj7FP;ou,A}Bf5Hefث.E߼~Sѯ8ϡwz?rڷ)i}*O.aq1u71^֥Y)}xL]# QFo71t&OFuoh`կ3=޶78oO3zfj(3Xk+c?֌?̘/7fG-1@Aiohk߼>ZGGbzq?8^^CvO˳rcjT-쨿v򬍱o;kg-u͎bTY9*߬\/7~v`tu߬jZ-򓬝oё7FmdkFmxԷHv>(:C׾o3ڭZmO^}GڎZ͊_P_?!z4niq႙So\oӠoy@l/s^ԍ4XFeC3zP:`"l+oi77.m!˖7^ ak@;H+"ĨRW.c6ȶЧň-RdBWz}aa )^:Jgzmqvİ/{|>cyBW=-[RlyU/u~-Z_RF]o [YgqK H) y<x[À3|3*$+&Fs:1{ȧ5>?qwט֭~R/=8 i}үAmGg1nNW=8& GZ;#kx8<<''ak~%<^T! F_ZC>dSӵ4!"bRDqr*Kx5?ٳsg&@J&2!>jY"W`Y&t0(x!E]'\VK>U&賠h,~:,c1A3 m0*bJd5K%lSűal4V# q$|*2`=ZP ([Ml:Q#j`} cfGƍHS#әufLdxb4lF fLbb#$8&35Iq+up)#fOz4H*$+ SXaSSLG!ʂ,J SXa+ 05TX@? 2%X.r!"_BE !3]=.UI2 wƈ~F8 BfRD>W7x)cұ|FL҃\92H<'?x0ٗ8B02(2_3%# q#5djs㰛Ksn@  iThM3"RdC\'H=ť8┄A^5)i2~g?J~>^!C8;w&;v5eq++f/:Ezsp$:0ћ]=9%J+pδa60V $׈) 5r$Q7Ev&dG&8"db>T"4*}D82p?xPMZVLma:C;]c,vJQ0 .'ibWkVӒVf**aV1Ѝ.1P CY`b'(UhjZ+۰vLmcPW$מ)mI ˵cLmX_EryLiOrX3)$#]`զ!N6W+vd5yxw*s:1Ol*taS° rȷpّϢ+,]ϕWJW3/3~…VG%--.~AU+CGzHwNgU<"=LcH! tfT"f"}XK#\'z^v f8h熾71E|?q=zr0c_ު'3bBf[bS<D>LBaj_3H8ٗZw5v:DG~5YF)|pu='0~#p}0WrifO9#jxYTUfo$H B.D7U7ߑ줹M8~TJg^쒔IO0֑G7OߴbHd/t.L`-q -ڮKMrh`q8E@Ѱ;2r"o/4"$L0)!r Sܹ&D{ w*2EE,2ɶFHS&;]me}w&k+"i3lHda+V"1^:wSYMD˓xdb3Nfi8ս̌1tftl+.b <ӈZ)LӕOp]v`B τl}&\(b%`ULŬlClI /aXβelrsXs+x A"+pdIAKȵc(| ۡ xn0e#0I3_P/`|231cWű*GO]|e3 3B7_VFqmmr: Ps?/]pG0>T9E-ws>R8 :b @0W2s8BǑhaP^^XW6AD$gTvt<"3> ')Od|t/wc  8qwOiLG.c|ٿgt]9x #xiJ`+Xᙣvz;=1i`|]lg0~q-fk\[Œ%ׁw+a<M9puũݟR]ʁnRZqݟaYx2Kt.|G]QX,2.}E[Δʜ"L{fX@(K{q!,%+(T!XJx_aTůwfUb Uxmsa+8jYng-,ڶrd*r-3obXdˑ1ț#8Q^]fj+PGuf-#Gs{#W3*wf\^ɭf5̸v0Z湖y!Z^똺W1uS70Z:F^+\?r#>q}x'#`c!t)eJ+# _reܛ/g|uwfnb&z,xg9  %.U l{zl+RZTJ hMJmc Wz\<+'²0a|zYNJcޡTJ]Jn% RC{݌}h2~湃ecyd,CAWb߹Ip=76eIeɁ4In`73FsDTzljoKAj{bItk3?1$jv;XUp+bW֗2~*16VG1~+ڋ t˔HV1vGhϔ$w;c;O'9?$9I'0]1|!}q&wĪG*j;¿ktܦrkxo%# iZZ4<"<SJq4< aQ.vN%'ܿe5N;vvpY4o" 1ZZ-S\:U.d#9kL񂨇2CH497cOhfdB@|Q?d%B WF鮤8G\=zBIn'Jp7xZ dC$ϙė䆺ifFz-GVn xglDVtꖄnROw`=_(=0KRFVa+J/,IA??LCҟKK31&x0;L/kB[,AfR`6qr,`Ks_V=PZ^&`xaC)!aZ< SC~7Xdw| J?8{3ƯRv2dJkoe̚Ug7Ɔ@7ťCˇFl[pk.E+`"4RuPU#mɺB#~NjXuFe6I- 4g_i7l"'N£lrPÇ&z[VL':5n`9S q05qrb;NǬ0 h4Xy;cm:C[5t5Em[y65װ1"$7;+fkۜ|1Z[sVmqNn jmX^+ٟ}!cJp:hJ¢2KRH%8APL_pK麱:ʩpu;m[nKbqQ2x0bTTGRJE3':| S 8b;}/l-vM6[c>7#nbQjkQfIdP\TjQ !n=q9lWTF[d10Ơ*s<\|3i?)QDh I %(t ӝ{UNZ?t`X5BQ/u 79 N7h,h-g=>WN znO](q,p4Wx'5ow:J10#ե\~Tc]ScF92Õtq,y'vӀ cdh/z):n1tac#TO)Hu uG,4^`9bp o&V*o'z 0@Dc/vPkk4;k_*%*vc 3R:w-ط}m-|/ ~JTw3j2y DPY w;&v=0^#=Kr0صM=KO8YB&2JBV.|7v[5>TVؽmU-,6(YM %M82**Epl}?nFskn3:ؽ<w+qrX '-*%$Q+c65c`hON*tduK؃T JQu=]@wv=X3a%8F{9}PUg]"fGb1a1W( gݎ8ft,G'ku6[,AE4*BCi=}((oRPRUѩfKwh_@G桩i,84o,Lt].Hz'Ѥ$5=iKY<}5v/Ɋp`Igvn@?xdp]Žyyy;w锟E@-擣9+ѻE^ >a4 ]~(c0Q6]OFa(nRx,,cZN4z/cZXWhi׈${?K84BJ`Sv\ns7@\#n?>A-pG5?7E_U3>jѠ"?u$1sgLN'kT, cZzZ{+El 艄edsNv}X(5n,Ebh>>%z9]C@3s6N\6P, '֐Q,IsvAOĝ%n tw6 a͈;EsnGmySlo%>cawܙ Pua䯅ځ(Z譩w+XOwBےDS<k$)ؾ%Q^LkzH-/JvU4թEQz+%6+ֆ(^#oװCFyۼCB^ZBPw,ip9*񡘈Td&Jz)2+><,R }Q:b?~G-aazܦIH|$bJ N)m:eW3%T:*u/Hfp60&,ٌH@4;%=Ώ GFȴK$=9e $A(u'S ~7*KCKmx28Fbu٦*D_ԣD!5 |>Bܔ1-OJְ/ TMl2kBz5%)}KyĿ>x;|nJ3IbЮa~s'=%Z'sM#ePSK-gc6:ՑZg2p*QfcVI6z#1NFZC_DRZ@ӯhe&9jnIޤRDK+(We:hLص e6]jlmSzWZߖs'*+8KSluZsH\U ?qkS6z߮Tnh.%yzSgOR|R Ƶ*b Hf-Nˣ w4\|%ߗm*N E-!=c OSZ=hwLDz)z@BC&O'ˉBi5~V#}? ɹnebaZ7:)crae|.\glLXsItb)dzfbkkF-V\հM"m}Ʋ6H_P>:H|bW+5|[k )aڹ8e%ՄWdk[xuMW~Xu@2[jj)" 嘶Q҃1)z|P 6+2k8n"l_)6vRǴT'^Nҁ`/O97Q{bqѿHn5H(M1Dd <  C A20Ęq0{$u0] 0}`!0Ęq0{$u0] ,tP= _0x}|TUof$HH23 C@BI" Љ"H"(Q@U^ *˲m]\ˮm{y}y#cφ̛=sϭY4cCb(nx8ZGk'৺ZLH44mr$iψ\~JԾs}.uOnˤ ]9^ρ/\A5-\a\ѤY5Qf./q)_F_ ["unGMQM_U܎ÞIW ndx^?.g9x'^_مZ,:%^FߌA1s殑aBL|Mu ڡpמoDѳ}3l$jE^MطoZ^g뢘 콯.>7+o"|"Je7t]o| |3DU^6|?-z/g]oL|+-2Ȃֺ>Efb!rlxI,x]`zq'̭ψvak:6ҧ]HӭjݷwErZV۾%k     & !"#$%(0)*+,-./123{456789z;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxy~_1034858079'!mA. #궩#궩Ole CompObj~ObjInfo !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qCONTENTS[*_1035171641"!mA. p󶩭p󶩭Ole CompObj ~VjCD0100ChemDraw 5.0figs supp mat.cdx+f> ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialC MM G01 MR01  \ a01 W  `OڽT3UY       B01  G01  =  ͪM@ `AcOMC6CDE+FGHM IMHJEFKFGLFH  &= `AcNHf?/?NO+PQR+W SWRTOPUPQVPR   8 `OAcڽ ;-:XYZ+[\a ]aY^Y[_Z[`[\  ͧG `OAcEERbcd+efk gkchceidejef   L `AcOOBOlm+nopu quprmnsnotnp   a  j  `O@hh3m  p01 t01 ~01 M01   `O @ My       M `OMeZͅvwx+{ y{wzwx   `BnOsy|}~++++++ }~~}}  j `OBn@m`m++++++   M@f `OBn @i\i++++++   ft   X  `OMVW[  j  `Ohh3m   r  {  {  `OMyz~    `NMe2ͰM++   24@OPW ZM f01 M"01 f , Z101= '  `O$3%)        01        01                M `HOMM +   f&  `AcNH&++    ? =`HO  +    `OHM+   @ >`HO+  @:; 9 `O8@8@3=  @01%*2  @D01%&0! N01'&."  @MX01'(,# !S9 7 `O@ QQ@V$ "I% # & $ !' %!"( &"#) '#$* ($+ )ZMX8 6`OMeUVd+ , *"+- +S7 5`BnOZVIV++++++ . ,!-/ -@:6 4`OBn=0=++++++ 0 . /1 /@65 3`OBn@9,9++++++ 2 013 1@fD4 2$3: 83< :@1> <`CO2HM/0A  +      = ;<A ?    B @F  1 N NaOH(aq) MeOH ObjInfo!CONTENTSw_1035171677$!mA. `T`TOle *VjCD0100ChemDraw 5.0figs supp mat.cdx.H> ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialD} {< `MeSO3@?3:A~ |A }}~ ~< ~ A@ `NMe2MD?FEFG+H+L ILFJFGKFH  f2  `O&5f0f53 C A29616 !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qVjCD0100ChemDraw 5.0figs supp mat.cdx0._> CompObj#%+~ObjInfo&-CONTENTS.` _10351717221)!mA. `6`6##  B5 $$$$x ff  `  xdLT4g(dd'`ArialDU S3DPV TfM K01\[jW UJfU01\]pX VfMM_Y W3Dd01^_r{Z XFsZu s `OIWDXI&][ YUV\ ZVW] [WX^ \XY_ ]YZ` ^UZa _FF01lbdb `Uac a= K01ndfd bace cM@&Af dceg e6Fv t`AcO9I4<9IEF+GHIN JNIKFGLGHMGIh fegi gfMf@t r`AcNH&P&CK2PBOP+QRS+X TXSUPQVQRWQSj hVik iF3;x v`OAcI3>D0I=YZ[+\]b ^bZ_Z\`[\a\]l jakm kM4Ps q`OAc 7ZN2O7[cde+fgl hldidfjefkfgn lcmo mSPw u`AcOVSQEVRmn+opqv rvqsnotopuoqp nWoq o9dy w`OAcZ<Mb7c<owxy+z{ |x}xz~yzz{r pYqz xIm| z`CO2HKskGlM}+ { yYz 27]_X_]f !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qOle dCompObj(*e~ObjInfo+gCONTENTShdVjCD0100ChemDraw 5.0figs supp mat.cdx- > ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialDM KON LI01TSbO MS01TUhP NM^Q O c01VWnlR PXj h `OMfVW[S QMNT RNOU SOPV TPQW UQRX VMRY WD01dZ\Z XMY[ YI01f\^\ ZY[] [M ?^ \[]_ ]Aq o`AcOD7DEF+GHIN JNIKFGLGHMGI` ^]_a _ ?i g`AcNH A1 AOP+QRS+X TXSUPQVQRWQSb `Nac a9o m`OAcM</<YZ[+\]b ^bZ_Z\`[\a\]d bYce cIr p`OAcs@GHTcde+fgl hldidfjefkfgf d[eg es ZNp n`OAc3ZQ DQmno+pqv rvnsnptopupqh fOgk ikl jQkm kM cs q`SEt `alwxy+z+~ {~x|xz}yzn lQmt r k  `O@i isnu sktv tt  `O@rr3ww ukvx v}y wvxz x{ yxz| z  `OZ3} {z|~ | ~`NMe2++  }z~ 14 [SEt]@TUm !mA. CS ChemDraw DrawingChemDraw_1035171775.!mA. @@Ole CompObj-/~ObjInfo0 Interchange FormatChemDraw.Document.5.09qVjCD0100ChemDraw 5.0figs supp mat.cdx+> ##  B5 $$$$x ff  `  xdLT4g(dd'CONTENTS_1035171893,;3!mA. 0g 0 Ole CompObj24~`ArialD @L ڤG01 ڡZQ01 ڤ \ @`01 MV  `O &TMTMZY       MB01  G01   <  f? `AcOMfB5BEF+GHIN JNIKFGLGHMGI  ڤ< `AcNH?.?OP+QRS+X TXSUPQVQRWQS  M@7 `OAc @:-:YZ[+\]b ^bZ_Z\`[\a\]  sG `OAc3EERcde+fgl hldidfjefkfg  3L `OAcOANmno+pqv rvnsnptopupq  i   ` `Cl͓^_d  i  `OZgg3l  @@r  `Oo@sp@t  {  @  Z  `O@ZZs   `NMe2@@wxy+z+~ {~x|xy}xz  14 [Cl]RRf !mA. CS ChemDraw DrawingChemDrawY2m>Y{FR뾝{6};.-du7]Fqƥk'\X~ smoIY.wUGZ ǘm="ѭcS kt D[׺Ed#y,r[E_6^Wdr!7o=yrܵgS[ׅ]ZCkSmf\O4u׾oFoO6Sv3r#Qˣ6} Ry7#=L8׏,7gegiEz)\ӟ}R6Ίn%-'XyC}^gVgB? 1x_T{.mzJ #_z"늧DxRϗ!qd9wůͱnMK~/-IquKox'P5c5}}7&ʹy,}NN1Vx~qs$%)"G'YOnG'Yg G#JSt K-RS%)sD۹ƒ䭁s.d%I/KbzB|r%)5e2gu{B4"[{Œ$ɖ3^ 6b?_#&D%)NJ;ںFl$[Cź$inpƋtv>AԔ-ex!:߱]GПоoۇ]4zctDU`nZLf8ѕx6{U;~۱r<љIBIdV80q \r|8䨧9͋.95g+ansKbY%(S5GHq9OVh'x. |MjLIsH܋fE3^G[F b"ؒ'[x9=NiA h:8#6l-F%)Nx{TOҼs"ؒ'x91k/mI'i^]d%I Sd%I/]^~OxWE%)N3^ Ǻ ,7-IqWV7l%zFIqW.m%z}dkx--Iq5p)VDȱ+E'YO#JӘcHsm[4cH<Bɣ~[r86bg,!7o@?6|zn^FfFV^f;bV ]:d5_/lX՛ŰWl/ɫjM׏WGG-k/$liQurE,fn|ydÄN̋WƢ,Z^9&:Xi,jtiSC'ܰ4kyDf2&?Wq-g%m,Ո3!4O4kh #ESFOzpC2 GG̈jSD4ٞaH D\HDq5-7Ց?iWSK"]8>D`AJe0Op6z j'Ej`MWe\HM@A21c2Cu1hC?U7zX9M/"! ^06?JtR"6U=%߿~ ?C[6M;5"N0LFu 6z5&J#e~ \i~*5"oV[g [8CpD&;̜l%Cs+JXP}4TҰw WJc}JA>3'?'?$ ; l? ; K?Qp֔ҜM9[ޜ"ԍ"Oτ1gބ~1N+N iELUhMUhKT+]"T! Wz$g/*UhGj(ےDmkv5(ׁ(P-ɵ'DmoDA t@$ב2Q;]r"t#8Lhi2_+`)f K;R2 'tyB;XVXzo5pFox mK&v~ /bd_JRAwR>@Ur;¿!_omVNƮ<#N\])(D>wFAMMؓse{ؓxzO_Fj/^N\ r&jQ2k5{S K}w^2KCk4 +~g,44N.BJJȳ\syN )'/50/d #|H /V{a$E% P r!4RV 9pݬ 'W)E)hpd^[Ø.L!\KK]B  /&%yЛať5eX5ln͎Fw&Pwpf+kW)*(Q>X꧔+*%m n6QRʦdls/} /ṄKx%!>[8ڨ0|Yj~ oJFSZ$9Ǵ쪧>C"GÓNCZ ]Gܑ-fuOuXfeoBKLi76'q: #!o=7E` IdI49Ϧ%lͫ ѻk. 9:͋Dlxn."f`f*aBy3_ lrt>9:3W>Y6|ᕄ_Ṿ̱Yf s)q.u8Մ//Nªe'gmO--TH b gB Re/%5|gjqp>o!1׃W<1o9.bF܌"(d"4wk1!%p+(p+RJ0^G#WQXV"|k_AJ뮵QWY"f}Ru!ŮRn Q)sb u9|7F~ƿ^zJ6Հe(Zx$jV`nsl #U$ }zx\G"+ a"DVVNUE6VYC"יKHِWP]-0gZR;@E:wU@q}%# ĸβxVFYD]CMD݀5D]KDȬ\KBM^a`+M3*a4%`7QBr̈́o |nnV"F-V9p$x8Ȇp y);؇6خW+JiRA)RnTx[)@7R~C6¯w8.C<vpK<;g'LNopVHv ExuԜ[N`;Q̼>!Ƌ9ȆUм r]Յ#`P܆I_i])ݡTJ]JJ<$o)@QS&|?w~?HA⹝dG {AcÏZjʤ`Qw˰/,0t#Qn@$LԛŦBuf:F{H{%.9y (6zveC Zbc1hVg۟ܔUMYr6RS'ys ܦOV$u%%(w;Q$;zQN&~CBI[Cg$5[}pUa*C&LNSyצ<wL ,q`96&J?6p8E3.Iq" tm om _h ǧ rekka䛛#YPTy_>}I(mO~"/+vAMץM!)=/ْ#Um--%US|';}'S6fIϟ[}'>^R=Odfp< 9] &Q,,8G^V\cA xk=k"艁kn'Qx\ژűM0A hvp4y_"kՒY 4B={Tz ~g3? pd< y~ א˟'Fp5 u0 \)k2֌5;XsLd-XKSZV\x)^+SXkpBlM  s/}p],^:@_:ò[܅]vױXWg]Y7n>yxwnp r=z={u. 9yeޚQ3Y(WAzD. r}59\(i&ϋv5&-YxWqN9tk||K@z rR`~,Lac.ؑ徕5kx5w̬Jt A,Rԓ,ko}=W);\px/+q`̍ډmަߨϕӚ鼾sRh_iqfțFztVx翲}yo ݁ P:QͩwyqbVb mm{ΦwW?jxwD o [O:4肼oTRP)[>E̷)9w.ECޗl;'MԻnf'Bޓ:ܒ2:I=aw!=0-EgTvoOu_ w7]jz@>msL佑x'6>e-J}ywQ}?Oy.mh)#n 'зj;/o14쨭z3E?ǿyNaEݿ&-Y4ya#ZsqzԐDl!oZ)~M-3l3kbG5dɞhtl |Jgc["/ylYC$Y̹|+5ɗJVYi1YNG(Z ՙZft MYkgFh?QwPac;nf pWu Էvβ2l 09JaR*`,6U˶*XXDdq0*VDnY:N'=D0 a_1&e e_ɾ9Q)fS%҃>4x/h=höe@|k4PX.*}+s=Ŭ>f[Y}"yr.qfyRd+̒j̤z`ߊ};/\X,ی?eJs7df}%*0==n`;@DxV &Q+ftri \,9-*Evp3XkH'F*|9R&ڔ9o>/UCCט5yl[_60S3Gh5b4,m!oG5ԁ,s\DB#-Qk0hL-s+\j5If.N SۗuKn Ez1q fw,Aa{w6{9; v:,{T5 3XeWfߩ6wҹgf7'GЖ`߽=kwo6=!ufA> |ޚgi\ᑩ .IٔΌ ˺ӊV_V9l|YѮl8 ANk+PtaRK0+ 7ڶPaj}>icLĝ WeςEQR,Tr5VbrfGPղ= RL㚋^Sjkjid[8[ 6?͔<(e#(? U^Ote2Z6^<vͷ}d1;pVAUuzO0.Ԙ8X)m]Xcdu.!?&9>vWV˷G+T6e)IfBS4?Mw#f@35f1E,faHvѲ+͗kܷ`5pf]Eܻ`)a]lx"lҭ̒jSl}:[$bMN˂eȷ~I# KQfIJFVb;NcZ`_-pF>3˯U Xe Q%ؖbu{Yؖc0o~*ڜ Ǔ2+d57ص!!l+ShVU&uhw[PYA ZU#D86D>,SiߧNH·:i P(FJH7rj" Vb}lEqF#AdZbpej+D̏\>UYq|`*N\>,UbHX"3 1ūi| @b]-PA8XM9{|_RlXR:O=|np>"˗r >Z|wæT߯P, QQ³jV⶞gm#}ޖĵZmV5ky06EXб1~RɼHV(msp{2!@ؕ8R]$%cNVk+A6AYoe7gLŏ>& 6N\G$|JT4e5 )-% \>9+}q -ȵ@[G[):χ9S->.Yp :P.nZ&Cl ꙪV֘-;[i=k[=ݠwIE&ӑo#R6)2 GcSz G:Q2*䓬 +e4R M]K B4"U&cBܘAŎ\|%66۩Q*Ko1rG]m|AVǐYn KPIQ&A!URv;D7Nhߪ b7(~c of77̭59gB\>JoQ(h[|l)H[2%V|U>nE@۫W{k.A=d5 6قѓ!kǣK' 縛?yr)Dd<  C A2(r!Kгh4RD(]`!(r!Kгh4RDL h=8 (x}|TUof i$)@H B!T&P UbgYW vu]VVw߹7ݗ7?r9s˼9 0Y[ y@]Cm(oKcrhw˹|''_Sgs=~`5jj?*ĭc\Ѥ5Pk ,Ώ; _11($nEjڪ+zɚ@oNnupOI>w/K築 Bb^vںW@ ^歓:Eyf}f]%zԻof\_vL֣oN~BwG E1r CVvk?(^1^=<膯{Du=(:{]<]!_{D6uUzkW*^s5b6_-$j稷)3VӌPì[hvHڅfh^ \;8B;+JZ1HQt9[;HH<|Ƭ}#V'DXGZzO8z7b˳Zc{S3ɳFj픘~]XsZ0߬H73璵Ɓ\~@4wH R=&.̷J[mZ:۸,RY9Ck[>V*Իob֙էobqdm}[3Z{U]oWJ狷&{RIX{YH=ω [ x|?}wk8{C;&$RټM*>OYO !uʙ˳ԕ-dL#m͊}%)nm3/<ņr3"c,smCjk'&5cVnVqڒ7Lg ~ͽ-Iq5qyJxEYIq5m`8&뎗 >𷩭8mIJ]A_RW۲_ /}0@m}-^tl_)׶g(O&%)n&.9ؤ896)cŔ8&k)r5w{]slxN3~ޗz{oՍIa \wxܟμt9qc&=!wNhsD'{J۬᎗n-N=}8~I;.cՂtN7YwͤXGɺ倛:'uw&k)g8&k)ڠ8&뎗~TwQ[9qڒ/|m9ӯ8}$)nmȤN%)nm?'G7}*N[RWv0s&jU5&.OW.);UK.sq2;weH}ש}zw&sUmG}W8|ޅc:3qɑuyn}&Ͽs(3;p&.9&p,a&.9pt`+UrRfVL\r]%Gص34h6n࢜ܜ/4s36ξh]rZcѝE!\9 ` rռwɫ~nD6m$4w"ֲ?%W <W^<.Xż ɻ++cqZY4ig>Q6&VIv\;.-hyoZvVVcYM>% %\SK!jSCCD(YrI`#)oOQ^9<ѻ]7ۋ ww%mQ" @'A~@CA[)>fDMTbo^#u2pf,Gӄ?CƁgNι,|dn b4x H^(| B~/B;%K){I{] K+HQ_%(ǔm趤(4gY܊-(vCʵ&JKemErmeEbb>ļAqVnds8@X6,TVHMx{%oAbkg}/ځDڑrrUJ6cH" 3/,e&V+W"܃D:HG˗C ^'QHč4an40EɺΤ&P_ w!J'jO@ ԕ;;n#1cҭ#dO.tEj6Q;Qsډڝnfg dQ]-$|`Z:*UCdx 8Fd+-W"R VF4.&['o~7l]Pyٓy8|ҥuZ,{ǁ r!eRޥf#'U }rr!ix/}L ^ zt_G<'H~]d?%$"8 aC?'Ce֋z2zR&jO꜑x u3"AbJ ؖ_bsTOdğJZrW!g,G 7ӄ!O٥N<&H[¿"kk W:l+_~ږ};{1{MKV/$@xHD "v/LJْ{l% EFtfr'/W4IIF$*#Nѥ3#ԒNAx- #{8@8'\smM#نí$GGR*^rDrI?iLBU^@`C+3H1WY)xN5{9g`RSD2SPL& %b\n&|O`.7 r)1r QJ#Py) 'J %a$7lq[r#2冑+%:Qڅrz8^m8Nj+ؠ8[FjF=L(%ʉf0auCJgwm)!덶JHy1794WSMT4QJ#1dDxobUVrѱDt7"9-Oǎ N@i} @,:qk!S$D%ReA~<{̌,-~@"h? ªYB"IdJb'l(,˶Zʦҩ-ZI&Dڽv\.'|i݋Eo!Q[( z~˹;T > :bRy^jBn1.t^.%|qKlٙJ@,Q0N.!;9Mqc`zmdZa\e/܍x:OGNxG³]d'x:l;Eö$ˁw!7] ڕԝW(h %UDbU3_K8aA(] 2EmQ)% T Bn#$LIG+"/&?.4xg%|]dKg 0 /tdG8A$JfWQ\Cԫ^`# t}I;*OؒLIrJ 3G)whnr7VIJMQ^FX'^NxKgL$ EU"EvThфqm NqcmIjeһ`QVeE8o'V[OrHD+7z3Qo$]Ju;˻ ]G~Dk-aZMD:got(ds(d) N nv̴r&ez3ѝDKD?Z^c;HV!' .1˂eKO_!1tv9/qf dnd>vu:?: 6sZYPTZ2cF;|.?V42kiEja%jqxW,6xb$[;B-j=~87K »|ason啟f&&M#!| !%+BB-Yd.+Efv"YB>R6r6 vi9޶MuH#r9ݲV 9+JLWDõ1H6\AO\S|7C>% xs-eb~胼ŸyL!g.Ѝ +}b63bvJ &oy?q=oyߑ;,~ې]0Hc{R^mGbƒJ6!#Ŵ!`o76H鄑Ci3 _m@ R|y;xS_踁l8l`8>s19s `O K*oLik)'|h~s#'-ڻxd<<u4{y  盭Fm[8L#_O#59&g~/- /Txit Ɨ^Y߅Q̛yXj0A|hb.IalvCgFwF4y\]ߴ_ {_X*-9zh'ZrԠ3TÚa4XD [WvonKmJTN,b)N? Xvu0ʂ_B*%X|jH;l]6d_Wک bE캫F6Q W[dg0OI$0{XSĢۤVQ> Uc^g C1F[oNQ󼤈ޤӍX34EwXN7͕:(k ک;ba`˯sث-JUm\ԭuql+bc%m.kP>UCu[;nPv[L9"Be-=(STavrn]m#}wإo1\瓯3_Kgk޲+*(W΂[Hکt;L~Xy\aT75N鸃 ySni"M}pC㎚0뢌 Xs%K2dhdv+K@AR>.3Qb4*1;8,ķNj+?Eb9VǍ}t5:[p(̶Ekrڨ̹J1ڶdϊ}uw=6j n[u*B t!6B\XZ$ՇبXB=|6P`/6˪AU*+,N6Mig7;XΧ~3 r|V(o 5]n*4Z Qm{Fg+EtF~uY^2kvp^ƒ+ďx:4حXYw- zbT@EvZbVSwwXĊls>†%+0U#uZ~Vv씲;dc,َm06 ibe_51JVvmYК&jZR,2S't}U&0;fB \R)Qf(sm aS4)*v[i%:kv(OFŶbBAY ʊY{v`3=r VjlSTavK~cIW"f\ KdoUcNrPr{j,U575?t;-Vƅ},n-N2dh&QۭM_ۚB?k6-evslƍ}8ߚ^ʤ;O( ږR־`2g~[ni^Xa+ӌ؂mA;J~ZgAipۧ~,h\YJ\#PV[/-5yU/kG[,x\yb/'<ɕgSZyß),VE8yέ%,%vAe/S$"Kh545 BȿA_Vs/-7ƿIa30[2&~5[=M&FY669 +TVmf\jPa;H:)z@0^bkRDKElB,͕xh?!%S7惀㞌d(tH^g)[ς@OFHIW,J2jߔe i4YnJ&dXq艔^d3YC vJ:6Do 5Pͯ'|,*h>`FJ!k;wvj-NkvCP[nzbRtV1O_6q=h[ƆEvuRr3C%CszlB/6e6=wCuR QlB;Qۆ2A^ ^1`fM;.J{Ĕ씿dKjP^GJ7lVq N*_AIX3% ].emŌK>Vmm̘ ̒2p^|`'ȴ؏]&)tGmQ2E`{!՜] >.e q)vT\Ċi|%?2|$Q+9|*Z଼0#g B q` .#VfB&}b#W+aLHX85 Re -{IhysݟO~m6O#MۘbAIhRki"(%O"hmVm}`EzΙ{77EDr̜93+ <%U"IyI5IHR, m_QUjo {j5}=K&EcWu D_9,U\2@@4+**3j-ϊ"tzk!N3k &NTzl7Tx|&L Fg]Z1jýƨ%Sf`JKFb)_5bGA3KSsYG 1|.H@g`8/^\XjiI$&D1O(ajDNt< fkSP k xP#krM5ԾFq&-}Hז VY=rU )빖YOY=y /ap)K l(^ǣTB66ӿQl}2,jÜ5ov̀quX&Bof莿қ-ՙv e Jx6qL2r]T(,eI& XL_Ėhl1vfp@[RK[gI2A|/pip5ךQ*8xhYК<@W7}ƔYG1Ø-{XLچNASKQJH\݁27D;9Ink3%O8mvXTe#,w泛QFWVnMwP–٥tN!YN{2Y Mޓ}p*LpwEI-cRWKWꌃ)|n0` 9ukY.`:.*vhȊ\'Ue/!Ui+Ȯ !vi7߼-A qlEzG wuMăm&]q4}'c-u{9*f<ŕ%b+S^yi1gJ#;F P[.y:3{B!h~p?#<;iqbh^Gm,Uǡ[1\1FZbwPSYǫBjSnj@QhgoE蟙07_z2DdP0  # A2 uJBZDx `! uJBZDx)|Ч xZil\>3q%N&NpIqf08dMBb; IhR d 4JQPUUT* DnA((Er=μ!QQ*zs~I:Xtr]x*w5 x"0GDu2N0dlxǓGn%=.xtç/Q&QMFTCPK ӅA1*[(I^vTxeběHQ!YYA䞆HށяɏpCq3]&~Qazk>[K\FǏ/ޚU47a\:ߙ.xl0.6FX<6Fh ۉ xg(hU`wSڅkE0ݕՋq _CKW=2X;+K^kf׵k鮔ek>PODZjZ +Uosoef~q}Z}ky8c>]#+V9r.iƹYt;f>^gqF*Jl㣄gcmiz@-E^ck-1x{%|P8Q“%r;IlU8xJb}{`v|-Eǻw8ڱE-dRb,}w:맮MɲufG֙덱 /^qs *sF#S"8 }r+c1(\AڜjX]ͭ벹LG&cP1{w9^؞vuؖCǓZ_Sw#NM^[[0d"lنv ``^s8ݍrK },||_%xxEyS65,0سOԃ JNj3սB~<V3l_,x`^qj$*m:?pzBAr d,JBUg;-1<{Wf]LDZD3;G(V;Ce`KTf2WDlOn[ɷ [IʤZ̓ ]6~O,Ԛl'011K%e˜`F;draL2VmqBxʘjP5]IWP+t5wVB͞ d"R)5B|>e&TDfUF SKRBr5"W+ruBGej c?mn/ hz۴4^#oX%-o_ >-k "YdxP'{{h)o8|3>}mRӻCҦ(q 2񶳥!-ZFě-c`H)#|-;&TE^Lg "/cTE~2v3پΞ0e 9|UUZ(]jl/'&r} TI}~ ~]x i߬vlz/S[KzuIjzGFG=i MJ<@Et3@1ut_J2>)moi[Kt/V:VKm5I$@IjSډD/G(.T&/%V7TQKsmof'&=v.P^mBz-5mIYT<* /[fx!-gmc |s+mݾsy]i1f!Y$bw gb3RItRQyiԈ͹cysst.5jmG{9bykk^7v#-TO6<մ2MVOs3659ȯr uꭚ,#נ^.it.FR maK` uvcq(h( 4'U\5x4ѩ^> zܒF[Oslm.5d^)ʲϧjTXD.y]i U4uDh2JKq a)}&Zءr6׺q# 5;¸Jv tVus.KX1m]:,pp^a60jm׫h0&h򤋂#A̩QfR󍟇%4mTz[:j jԽ9 t::iU{BuKɡ#AƂI.69juќ\z9/ in? QF<5[wu,bzJ|>̑5f4$#4mq9i+gl"kچr:QP͟:-EݨYXkb=A2鈞iQ"xifl2sW̚X&tG6Q`G&aY c{*~zo' iZYOf4J&a;`Hc̊f :~ /XM/DdH0  # A2w{̄ߐF9``!w{̄ߐF9`24H Mx[}pUu߽w/}xH W F- SOm2$ԓNM5$ӦzZ'vݴf:nv6 c{¤'o=ٳ )RB/'|\L myV*AntpwqK 9I:i0)$Q؇>F^R{PkoKI&'N7!^u瀅 GeFY-#뼣nu߂>Tq} ΪgѷrMOJrܕϾ*}JlZ%6ѥ pWIאti5W`F 2?Ej\RuBTԵRu7]pv)w!mu#3 BRuSo{)Ό#V?X8Zfӷ޺n6}|3۾ٽv}Ht,9 v{^u߮|7]Q/z{o/poJ7NC΅kοLnOud{9$.g*}[/x.{r"h|-Ũ=(H)/I=XU )q}㓀F[_!WO.+6}W-Rd~+6毨/s_X3X۶Ǹs }!e츈׈qBJgH,Rd<缦XA)qsVEJ\Àcjƿ5d#5#/{̾V g#sJvgvx3jmٖ(ǟp įW#O鿕 ?o΀G+s!ډM1{6fW+Fj[= D}\Q9P=' w+ h "*b>Fδs̙hhI:⒔dg߆dY8I[A:)HԚHP ¥Ha;%E:`нj,ykkhM_hާ )?8Exo-+a3,d-xGiAC|qҤͮߕQLҚbjVU/D&W,E,rhq^"ZV=*+>:0YYEyl]1&)Hf\p])&?OV!Gd5Pih]\)&`3 b43&Q53f1E U3QWK;|:aIq+q68g㏕'#nhSBW&u\; 4C1]86vvDgdBIBHXk:9{g_,7HIf%eKƅ*kϨqhxMchș\.>mKX956-BEs)\֦eϥ1]$+rk3ޥC<}= xV2 G"8 =M{LIAjH@[ IhA"mmzF*؅$Dm ,h̋ZhöjS#y)hjfr1ȊFx^io]+akJptH)L -Djnkk].IwkNPyRо}8ֹۼZdPb! bfnemڙn|#0}Lu'EQZTn6/7IEoipPiwxf6 6Dokv2'~/d%&K'5`|$דr̆M!beNe/{ez\:rOU1yS0 wMZ:IA%1wy^0;$kN&#ju<8(G(ucE᷇ZT%Ug M J"ϸ>J\ӡF Bc6 m֡#7SJDs*%ٛon #]W8+ZJ]YKznz1BԩR|Jbɂ\XdlNUPr1{=l @ muP1.y(Z`18m`j ݮS>Zn4\#[*-END7Yln8!gd ObjInfo5CONTENTS}@_10351720618!mA. NNOle VjCD0100ChemDraw 5.0figs supp mat.cdxF-}> ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialD ZO ZdI01 ZaS01 ZdM^ Z c01 ]X  `O`fV[W`[       ]D01     UI01        W ?         NA `AcOPDL7QDEF+GHIN JNIKFGLGHMGI      Zd ? `AcNHgAb1gAOP+QRS+X TXSUPQVQRWQS  ]9 `OAc`<[/`<YZ[+\]b ^bZ_Z\`[\a\]  JI  `OAcM@GHHMTcde+fgl hldidfjefkfg   jZN `OAcsmZQhDmQmno+pqv rvnsnptopupq  `k  P c! `OP(OEt)2MS`NaU~wxyz{+|+}~++ xxyyzy}z|{|}~ "  jk1 / `Ol@ihimsn# !"$ "Zt0 . `O]rXr]3w% #$& $`}' %$&( &Z) '&(* (P/ - `OSN3S+ )(*, *`. ,`NMe2b^d++ - +(,T R7   14 [OP(OEt)2]z@TuU{CompObj79~ObjInfo:CONTENTS_10351722156E=!mA.        !"#$%&'()*+,-048<?@ABCDEFGIJKLMNOQ##  B5 $$$$x ff  `  xdLT4g(dd'`ArialD BM:3E CC01KJYF D@01KL_G ECMH FM:@01MNceI GZ=Za _ `O@Z;Z@ J HDEK IEFL JFGM KGHN LHIO MDIP NZ=01[QSQ ODPR P401]SUS QPRT R7U SRTV T.h f`AcO0,1+ W UTVX VC` ^`AcNHFڵAF++ Y WEXZ XZ=i g`AcO@;@+ [ YPZ\ Z*g e`OAc@-&(-+ ] [R\^ \@Jj h`AcOMHM+ _ ]F^b ` 0@c aHbd b@&f d `OC>ZCe cHdk i;l jdkm k@n l;&o m1&p n,q o1r pkms qmnt rnou sopv tpqw ukqx v+| z `O- ).@y wbxz x+  `O-)M.{ ybz} { ~ |z} } `CONMe2- ++  ~} 20ZUZ !mA. CS ChemDraw DrawingChemDrawOle .CompObj<>/~ObjInfo?1CONTENTS Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDrawVjCD0100ChemDraw 5.0figs supp mat.cdx{> ##  B5 $$$$x ff  `  xdLT4g(dd'`Arial M f 01 3Ϳ01 f f01   `Of @       M01   01  f@  f `AcO&+   f@ `AcNH&++   ͥ `AcOfͨ+   ͍  `OAc+    `AcOs+     `O3  f   01   f f01          &  `H  3  3  ړf `Me +       s  `O3ssM  s  `O3ss3  Z  M@ `CONMe2- }  ++      ڒZ Z  Z  Z  22_1035172390B!mA. ((Ole 2CompObjAC3~ObjInfoD5CONTENTS_1035172653@JG!mA. B/B/Ole 6CompObjFH7~VjCD0100ChemDraw 5.0figs supp mat.cdx > ##  B5 $$$$x ff  `  xdLT4g(dd'`Arial$ s f01 f01 f 01   `O @       f01  01     `AcOZ%&+'(). *.)+&','(-')  f `AcNH&Z/0+123+8 483501612713  & `AcO&9:+;<=B >B=?:;@;<A;=   `OAcCDE+FGL HLDIDFJEFKFG   `AcOMN+OPQV RVQSNOTOPUOQ    @01 01 s01  01  @    `O @@@ @         `BnOWXY+Z+[+\+]+^+_i `i_aXYbYZcZ[d[\e\]fX]gX^h^_   `BnOjkl+m+n+o+p+q+r| s|rtklulmvmnwnoxopykpzkq{qr  fM  f&  `O&fZf   M `BnO  }~++++++ ~~~         `OMe 3  +         `O@3f  f  `O@  &  ! # !`CONMe2-@ ++ "  ! 24  Interchange FormatChemDraw.Document.5.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.5.09qOh+'0HTlx ObjInfoI9CONTENTS"_1035172807L!mA. 33Ole :VjCD0100ChemDraw 5.0figs supp mat.cdx6j> ##  B5 $$$$x ff  `  xdLT4g(dd'`Arialn$ "@J@% #S01+*9& $P 01+,?' %S( &@Jf01-.EC) 'MMsA ? `O PMKMP&* ($%+ )%&, *&'- +'(. ,()/ -$)0 .MM301;131 /$02 0D01=353 1024 2 G5 3246 4 >d b`AcO@<Aop+qrsx txsupqvqrwqs7 5468 6S@ >`AcNHVfQVyz+{|}+ ~}z{{|{}9 7%8: 8MMc a`AcO PKP+ ; 90:< :s:e c`OAc3=f8=+ = ;2<> <3Zf d`AcO\X]+ ? =&>B @R&b ` `OUPZUC A(BD B@fE C(DF DsQ01LQSG E3Z01LMaH FW01NMYI G3Z301NO[J HsQ3\ Z `O3TsOfsTK ISL JFGM KGHN LHIO MIJP NJKQ OFKR P G^ \`HOIEJ+S QFRT RKU SKTV T F@` ^`OBnHDI++++++ W UTVX V__ ]`BnOb]b++++++ Y WHXZ Xfd3] [`OMe&gbg + [ YIZa _BGg e:k i `O=&8=Zh fDgi g:@l j`OMe=8=+ j hDim k25hchCompObjKM;~ObjInfoN=CONTENTSX1Table5VjCD0100ChemDraw 5.0figs supp mat.cdx> ##  B5 $$$$x ff  `  xdLT4g(dd'`Arialn lZo mڳ01utp nڰM01uvq oڳr pZ01wxs qM  `O 3MMft rnou sopv tpqw uqrx vrsy wnsz xMs01{}{ ynz| z01}} {z|~ |  }|~ ~  `AcO͠+  ~ ڳ `AcNH++  o M& `AcO &+  z s `OAc3f+  | 3& `AcO&+  p   `Of3 r @ r sM01 301 01 3s01 ss  `O3ss& ڳ        M `HOͩM+      `OBnͨ++++++     `BnO ++++ + +            s `OMeZ+      `Of  @  `Os  ڐ@  ͋ `CONMe2- +!+' "'#$% &!  26@     , !"#$%&'()*+˔>%Mh_kF̎SlNѯ\[sf: v|]Hl#s[`N&qTNQEJl׫S2H z_+#j ~Ԇ7pI_Z.]O }F}KTpg(7۾=Qb8竅'l-Yx%cpؑ1q&c@ߩtU5r92.J>ZT𡃷pwveQ\p}"%fcL<>akyرʤgH-+) ^q..G8 u֔p£x¥vZT2 1š{A4u:z0́mdb~(UHq h%YTὕB%ZtʳUkqI\p N;!mDLrYX7IpUd^@Q,Y!\iXd>$XDV2ezPY_ՅCy,0"#!_]#$P1vf~-`:P) 4QHW8C9K@xPTOHy =02:̘b$1&BF̘f bjy\'ETS3LM[{Jaf`JX$c)dL4 z2XY]Da TJVX kZmfRCr,WrLeGIB70ս*k .=)f3Jc ƒZQ)O.%WC#ֲ'GFSXg=剅Z9u_Z70q$\e:0\B]yg8j=ndj}8#!nqXS܍n/@q>W?\ V6MV6[Lm'8%aVxG91͌oc|3[썔PFyh~731SC!{ 5/<],GCHq9Cm's;4]ir'tųJ.t7dƯ,e|'WEi8Z8MTtX92c"z_pڮ.6r dq!3+1{]xn7AP?Ưg|?{K}7co)][1cIފ/.e$o]0ys ehG#'s28.MZ?X㓳280ODW61v3pDrLY`Ydjקh3Wi{x*=r\8pAZkȅ.Va.,ajqߐna y@/C_3l7[{XbΧѣ K؅^YԆ _Yq6;-i\de}L N|zY1/S1Xn 0uɹU :v^l:zrV{0.`h}\XY+<\Gx>Pb L[ԭŅn&ӝO;[yfVocȂ;a-nbpӔ(`v>3iM0Ix.\%!rʜfq#[`;y箫| gπF{`(^BD wߑFqp+ Q}#~+o8V3spmLI|͙BI=}5fvsߑ5K#;R%Kv$u86k::Ł"=2(]YG&  [mPE%P\EVXl*E <_j] Y4+u;Q%aCTQa=HWiX fRSdj軞),c@cOOODϹ'3x(͛ޓQ&Ygaz,O3ڼfz?itgLCt Ж0K"[!mG~ex31xSAo oz7~;eK~2*۝IB9v'IL+Y;V[%>J*R5bjߘ'zh$X-q6P*Õ_A1Zt¼F߽uL}ٖo &ă.80ТhVʋ̋/>ȋ+!u¦d &l YkB %.PH#&60lA [u" [T_D*|3Jep(EHa~㪖A1-B}Nb00!+(U(槨X. ga Y&SEgwgg&U\V@ő8 ,d@Z8>VZ 0b ",Foq_vQAM5lRԇ*Qln*!gagJ.A(lqAa mX¨߈sˍΏ¨[D5ċ#ȲQ<t%.M? W~b91,\D,Q*T?^r 歊&|FX,햂H"68>av6[gQJ]_Il aoG-ݰzS Mwbþ 9{Zݐojt-ܺq}nبc]zK*pO=O퐇3fggMkpYϹGk Z "+a9%IpO-k}#F>@nMnU9<1 (&cF//[m;DJ-_f~Y;qW$~U]MۙX`/{gIIS@?(oLy@*lhbl,lm x@ՀvrP vUNQ󁇆Ђ/k_i 5 _wIEa:e#B^ꋟZ-ۧih9-X₌#ntn=EX3IX:W{)Q߯wKŽdiRmiLm-бBq3c͕rp[|߲PtF%?MG٨'KX'qg,=@c2=LA͡B%#iDXi$q-/xſ ߮e8DdL0   # A  21?PѨO`!1?PѨO>7at4 Vx[ Ty~G`Y``a,r=X  aIO2d$ER eXN*8>帨EIJ-rGJI"6")߼׳odUMu(>"!܄-mU]Z.C럆}^m[rBǾ[-ɭ/,IAf蠦^5!nXBXZ9$qXs節aA Y>Zޢ*[5^Z+ɎjȡvK jV_^XQgd\kx]Z2)P]z_WWߨ O{zm]PߓA/[s-XYn֏xlj+#[`:#\lՊ-gm' wf#EC׏T\uIu]!]KO!xP-+^OscpWHyY} j\RpWHWGBU\ɍ֫pWh+Q'r Bu^L7bG6^Qikc`~Yښ~jsj--#Z+Clyo)e^Wgs~ l'[i T;YSΒ[E]])zEX'TuY  bmgh{x[H6_LdQ(W. 䶚mU )qxO#8 c}k􎰭3l!%N6b)Xz21xϦgɿ?T7V@|yVd2+>H@n~Yx%H =Hx7c_ eRv\/m+|m+nw'mEnUD9.mKԒQp GG36Ҋcx+crbs#Gop;v#> yxvX]~!~q;`wMp64r!*:˗{:---Tآ ;qvC3Z <l1hO")t{3gNll*KX⚔EeSge%e\vC?, b/ ۝mVRa{Nd"1mM1 /Ec.XЃ1/CۇV]SnrؿMQ*,'㽑BKnKg! ſ8eBeQq I}^La疋T TdN,XdV"I".ءDQLqBJCezF,AV汈E$ſ8J)IzlobZKpͯE~(sBkq/b'BK9̀3&1An0ˌXDYuG1O $1ņ%aȆe2WL_"2VX2.dҬ:EIa+`UL XDrL$ bV#=HB0սr:{'Őۿl.U2'wD*,P!"|vc,Yeg/d_8Z҃wQEr>PMUQ2&se ^E^zQH ʨ Z1Ey[^,32{qJzx{8띌/a|)+_2#{yqFeG36S|D' ގ\ٹ)\fJ H^42R.6xi[Á08Ȼc񵌯1H:5G='3;\9?M1h_EDp~[K9yˀ FB w7Y`$fHFfHfzGC od| yV72iX{}%XRn3tG =I7BVq^X|hЃ Fvv.2x#alxw3a|G~;5,c8i}6i0Gr2xfXnS3|=0LwߔޮS‚^-asA%)~2WN PEqcr$<=?ad!??>Ə0pI31~5f1x82u*c|N彰C<.C؆4V3kJB әgj!R@|v|x@fȅa YXmfa|:ofpP6]Sn#,r39DD[YZn7 C eDm`o6c-`~3<$O32uxq5@z5o4yx}{4ojw"r%I |bz] ~4콼zNLYۉk<%S;6&SNFF1^_/d1P'w^]J,X"ەnZh(LbFscz.+ð+A{FءrgYQu vv`QY`fG [R؂F\aFRq'^kaA#9HX y] AcM Ӆ:i]N#(u߅eJOBXQDt=?c/=IU wЯ ,.^dxQ<GC-Qmo;]pޑMh0< i>lMbP*X?s^Y}kzhw!z>y^1C[\뮂Jw$L1 ?\/5n.]=.gsemWו|D(3|8<edLo2w}}[fcm}4,-On(Y7,+od=́i.k?-K.g|f؅OvYaj·\; `+=a;>e#ъV#^ U91\ָB]x33QëE{emW@j./D>N w&,tP5BQ5AۀmnXRwgjD +flsSͅ!w>t=;"JŰڝE#]o^"UO;hF0UK<2l˅Ož,\`-'.LX[~E$fCd *Q]-YmxKj[׬~8Cd U.7.;+8/~NQ x+Y!+ČE&̃⠛-gW too;};W~ ~EWxR|䎯ˇ0DoQ 'OQņ4RƩ!V,wq]=t21E~|næ-iAO"|7 a^'}j~'[~Tiich{U_ǂhFǤpr>+l٫1"N-. A3|7hѻ)1 lw%c˃9u(Fo:"d9:LP=I*-ْ[ުFحaoGؗ[f-Zn`o ŮPA J7+j&Ta̢J3<5.v5N'3 Ŀr\o4N zfFs;ݻ؃g9dzoUQLe߫ W&VJ$o"qk+vsPϣ9yҹQ & Z6k{0þlf - /h9vs((L5-N0v]av1j+mM[71u Oz`۪dʽk*ػ8b7N?R,H3f,%g1f%o&52vf`wi61 1 s43f6cfZ}i4}3پFVƶ4ag3m%lc663m׬jalFڵ8 > %5Gpn{ \mqI;fN`Gh _|%;[Y\͂ylBIoc<[| hyq6K5{Vlh32zu'\20Tnc۵rb޽Z9OeW\j26N/3|÷ʌ-JfdFuED)3>F;1ǔq@ږ61O.xQu&> ߼eN#V~,RKWJxR1v(NV_`Y;:[{R]d@ey2KSd:YMkO[֩:ySIY /j?ƶ<ېR['[j"JtJNjI4& r>.mLc;"o8ޏzhkxLKO6#5^Ԇ_mgCE[Ԟ "6<>؆Y#a}WY$m8AzaY=x)[/Q~<)n^ƫfSmNkoP7ӄmãSq'uhWMRNݗhK['[]uNKUwWV]ݐ^~P\igŇ; dtU/g0_ڱ#&db2it%X1"pQlDzsBQWs;SM5Пo Y_]s%xw_{)FgvQWs;0<U(qk#}c7F47Gʂr\\Gǵ]@`n^mJ`$}-o6}G5>ǩGxOVxC| LFfyb. S=7?(,s;E~;q07Z~iѱ"l0v; lKynT9;`2wʻ /ԤU_BޟA,!X)}kq8OL`ցS"6Ժģ'i?wӱ5=0ǹJ<| Z)؋*Y$Q?_D|jf^9a;6f08+jn|]K< MZ74QjMӤaX,:%8Gih̠[Nc^e(o}ZRuZg|:+7:mu3j[;QQh{=c| ߾Z묽>^8L0a_MpGu֟*fmKYYLY;3-FU5Klhg\q<Z\COo9\G{R$O#ZSڽ,*Xjf{#H!vDfYbW]H9ck5@ִ@QT$[ osXl5 Oʋ"n\{8'Dڄݭ8U.%fO|=;g ˍQ0kX%.tߜ9 O3G7gBwAͩrUD2m3Uݬ9ꋩ`DjyU 2U+V \Z+UKhuջ`tDFF.5W~#cDj#D7Zv]L<+jucu+ڎO'[ e'꭬~%ȢK"C!W" RB\y0{(G/F5ܑV쨄HQVv (\gGՋ1v諷3+/i"k(פyB4f"~ڞ-hs{贛}\zby8U̷9sb޽kgB%olv oҷ5[:K6׻u^Ke镶ĝ"ΰ%jOb3>],%]+Ӻz_]Km[,QKf)˰>u@fj9.sǯ7uS}̬Yo>_>![hu@|vw}Q!1%> H? CŅ* D>ZPJǪ@6[6 !Z@j/:ZF&Q6Z_8 ZКDt}QӀhG;b6v_v P|Q A[)^ 2_Y@C[ پXvPk}QbkԉBT ʏ3hO|/N}{Kڗ{6^ދ8粧&al#7]goOZij0}͝Zk(~Ϭ׎iwaʶ>9wsKFc/eť"Y7sEakf\mc@_uÖX%9N_zEzMY/8 9lN_zOlh_YKrf~GV~e=Nsm%9tfmib}.&Ћ+dYvzdk@tb'n.~qNZ=>_ewζZ}Ycպ?kLZں_Ћסi_n^2$&kyNlZ,'ݎpz62-"J|c 1ߞ;=%O\|%Z&4,yX@?+rqt3Gw}UU}ĹzPK]:MĿ #ZT\-Q9eH>mѢꚩ븜,rtY/Y/I F[:SKź`\n^.l51\řk#+;UKgYA$J), n>enZ'T!q(|+ ".x(!IyF"aΎrI[!N ~Acԩj%PidRΠ@j1:SATQ3ɗeD_Bӈ~:O#,}SRgdpyb>P("[^y(UNtBuuXSCXRe,5FzɊFV(\[E#oV~6{D_aDomw'z%̻a-N!z>̓r=]RdF5Fד%0"]d<"eyz>%z_@D 3<+(&ҥY2a<ا*I(N~an[`6>Z"Zj׎mT3m2sKȚK f#xɃMDDK~/ΠROP5b8^8կA2x7GEAGAROe_9en Yr1kɗ9}ѿE-D[~dpSIQμ{8Arˇ6s_VWtaoz}y8BTQFM;A&T&MHݢ>R8\%UR˱f=;6I=XԐH焑 դ0դٴuB#NMzµ*N=qj5ȝr|#h4h#i> ~Ig2 %w;Vq[O M܉; ĝ`X5l$DM#;CgcȿжJ~jI!:v4MlLǻ3fL2|o"6Ӂ&'趐uzJPstIݷ!E '(M?QqǮNMtQn4* T#n$ԈȐ3KҞlDS.`w~C6lV9-Q.:Hl i4a00s&u ѻ ctpʖC-iGFٚG:  ;O[7OZMN`󕚹f"JCD?\`8չf˕Ώ8Jz!c&z3M9nc#vRF}io"6wRKDan-D#vߚAn XB, DE@j Zh‚ TLpq3ų}M!S)3 \9#= Le'gGzI BEZ)!\%ˤIV}A^٫LPtO &;;pꜳl3͞]bO UeUla=RKR~]LxQ!iRlaX_7_!HgTD_/RX_#QwXJViЗGSzDL5\OԾ&T#^[pGjdP&Fר)ڧ3UH5+Z晓Tuoo~rC a/C*,8\n`yW)#T<T~ b!X~}'/K|Y!1.|'²2K<6˗#|\F)$*OQg0cڶ9k58'pdqBqyVV(ȼ.P| I-^U'z^ʪٱUwWǏ-c'klt\Ίv}+wTl&pL*ݱ!Q;P1F=aJMcsޮ̏ΫQ3lxқڊ/T\a?Ȱ'$aG3#5Uv*P+齦4(ݣ@3)fgվe?]VHoGN.zB}+Kv;g7MlsK5̮ug9Xd%yEB8\3$8Zo/'u ]ә\G".8,EL@VQ5Y,\YlKm;p}t)7>,_XׅK!O<$Y%iI MAב׫ nyb?rcK_‘}^.j W> l( gZk ^nn|2tQTaBJvVsI;CLPuŊh*Gz(+v+Kd?UjHpRjhVp[ݮ_9:%w[CυW9)[p;/np yH건祬 s]KmW44ܤr;wWǭL3ʂ8L9ӎ {STҚ~vzއmyһr!##] [t4t Nj,/$ Dyv/܄w.BvȍsܡgP৓^횛^5GJϰJ~Vﰆ2CUFVU nB»SLdPҰM@,7IuW [ P/yx>DELӝtOgAQYZmXӬe]lxTCvp8r3qV.7vVj3:kcXoBIz[z' fmKfe7cp}΀/χͮ_Yo@+$0!+ /*H#:7[nz'*֧ VI\b%k6=r6&əɶEg7YEmKZƆ Skv3_}=a/\MP[Ɍ6WO(n@ v yKI&p\1sdy*_]wj䖒dd3 >ߵ,>딼_䂼g÷[$Y,pzN习UZ> "=;hE?w!k:X>+PbYbx7s{ ;$Y>K,i;Zf>2-/6[$ OB#GcIl/<h\ȍ.|Ku#(FZqbYѝFOP&(ZB+{oVY㵣2e(CB^mQER2ՆɼTtQFgpjm2QIU2u$W0h12P3;m7f2p78 "V}7Q`k=KGD޳{17'O!3ѠB{i\}!orڸE#7bӿj9/U O}Ddt0   # A  2πcJsO[S-&_ _w~K- g:ce ?0/SjQgZ%Icc?Mv ybF]≀qƑ*x|!xxܠk&Nڟ M^nפ5$P ñgO n;;H>%VA<zX t{N|bUcD䆆J7*u3&3Lz+D\7D`'j,2(35Ѧ6֋/'v|l%ni#]ʹ=6FDH,iv%b%clN K]+}8;Xq8KkA1?qhY2] ikMY2]W6YY+)޺ΒVSS{x<0WH,|`}WM1V?̹q}ա]q i=.V5j~\x*n߅;V8JQ̻{(VFqkWbim_'k;q V}`xKBHS{}$>Mv~^>Wg@k?.6vͪ>Lc3mHk=6sFVLg?.6kFM!,#^%E_}۵[\kȵ+ᘌk~? ܝk\q=q  &1Z\[ȵQ*3Q)®1Eo2Z+f\;-8['UE>2N\X[L2-c;đ@!];jYCY]p ;:g0 ȣsV#>?T|Ƙ:cHLRBzSl . wA@ fQֲ E > 9. oDe[f;b >. IqavQ$D!-Iq taxՇ ݀[Ė<"qyDlrxlIے79,:$Ctݧ^j 1lexؒ7[*W[ҽ&LHbKRd_I»5ݻW]mulz?ObKRd{7ś/ 'oԤٚ$cdcuwٳ(s^]QfA"o3[=Sf"Q;Yt̗XfБċVVUV ObttỶ[͜#I՘g V3䌣v8on^$Nh+q Kk>UxCxp\HUd>y@3][8 S#[ |#ޒ v>9уƽq~}GA b@F(K)Ĩ#zG<D~5EOJ'jO[CZVO(QLx) Ia&Q %ӁEl C$ Ia&) 5PyBP.$E0)(!

pi4SSԉgS"&,8Yֈ5Ɵ<} {r ƞt'h<%oSɋL5Rˏ&%{PMM#S#|*JJ;R}pyDͱT1^'QyrmʓPyŷ:38m^dp&yrJb" I$"%w9rOYcM}# 1H#$x-ڤqL4+- 4vI`77ɻ-]$fU \%yWSs)+)kل!|ل_eKсbw.0W@ccP/C>$j0I5 Nw:k:yȓSZ(io e'zo &o FovPj#eq-9)WDJ%bF 0=d-}]f>=W(%$RD5oL9>U6R)6DfC,9jJ"}l"e$RbY*ҕHDJX| ӟIQ -kuGV戱夦6v߂ B‹)%ԇcs UBx*1vmJx)H-#j݈z*RcD-'jwvev7)DfE~HC.cK4o,s ފn#i,JkZPZak2v+cw bJΝF +ψg>NK .wYHw;\dǁ/"|ዔ ZJTPoTK>"H/x^ %2y1Es+J3W)JkҺOiU`R(EL q'5? xj=,tg%"_Ejg5! !>ٍ#هZ&|-l5QEۃ٧JjVZ ؓ(U(WNr$WCjK.vji01o<`Q K#Cƫx Mx̹K ? 9MP!C?(Df7+ڢ*mJqP yS>O?A=Mov'g3E<[g+>MV·>m>'9Wb4h};{)eoꍾDMANޯƼVYTk1-KZ(W) lQ#(~_"m(;>s8O8\l I$cq0\|H`6G,OHPlAMB=0x-f.Iȶ.Ȯ ?r?FaɃQD=.YQD$7FuYV<3ˬUOK[$yȀqVOD;J]JYJTjWT[oR`;r^'|'᯺7}f}L>%{|a\I2uL g,7C꺧vwY S3Mi=FwEB{Qť#ZrPK%'¯qpv=d<`_ M.Y_:|x;\\<)WdKۆy\ٍ?N,yʛէ;xW'k@>Col,2 W& X KDjry$$W\ SaAyUD h]2{\ ;5f/zvQtSd\|,sg0+eAfOWcf= hxq>Qκx@(7֕YLlz$WSmoPu&_J3a:u6ˇE^Nm–q6Hyfl*a[FH7/Q)*6Mے3'jmwTػy> D Ye, MF}.ִk%ιq8s5mhr]MXJ9Y@];$g_>f %a':,8. h,.'g; Mqt5\rul9cyX΅\˚ԳVuF7HuAPtdiބ3)lֶ0;9xR,3kqhD|֎>Սo:vRWWYYUUٷOeJbPOt"5~jԡMX>{XLQЛ$"U>y5 r~c{ q]r %yaZӳ~wAI>_=i6+F6v)9cax`% 8!f;/#>҂:0]!Sd"\>C ^E\{kڌ`V"rxN>A7l.ߣ.|TضˬA` b;ygf>zcq%9H{aر7l_@U wZO@Dd$ 0  # A 2բ0zDqFb`!բ0zDqFCL 8 x; tUUW '$Nt! ?DMO"O #hOuWE9{q~;{Y0g]Qgu*\'^h)iwɊ6+iGR"h.R]~F Xo~ ~*(o bbMn I^n%ġ mG^dowpb{?`nk5me*Z䘾}N-_eTWԸ熄U,C3dML/҅kXŲ;wgO1=PF+uc/n$?wmjXN_R3>vfR~|3ud)lfR[ܷCqi9p}b˿& .g0dmf7,ɺѿ-zv#\ |q cvoY,u/%u;){5ppZuǰ}p_ Ts#ٌ["8;7gYoy Lx hso u;yeRņhYv7upNrVmnhݩ>VmkܻSmaF6R hݩ6v\&wzMgcnhBN`bNý;#Y]vC\Aﲕ;` 쿻G]bsMԜ9n+=dOhc+NC+]a~E3OR"/ԤK:ɼIovF;8O[9gW SfzR3W\Fgĥi~YV@fzo,;ྙ)Kyv}fyHߎY?ҷXװ m[]ܷ(ICNsQyPSl,< -E+ɗk꠿ 9iC_J{  s195E^Jڈ VYcwxjd+QK,#.qx \M7#qE]Uls]x UǨ:.qxmﰧPQv残cxMx4;cxMxr(s%{=LquO.N>a@ǸtwmQ:.qu<;?|)+qagǸ2ᜢRK[VYîa7bL\iO(nvKTiYJklN)\(F%<^FUOxH*|7ܰ ?XRp)3$>1;{5{z 33S RquQoa^<"8/2J|])xKI>a$OkD9 9-黺pVng-_`XB#RgIR;]{/΄ Z(TTj:O$c]II Ϻ1IWhT T:1k mSAѯq`b>%(2"-Al5#!L/D8BtGZD0Q_0Oz$\#/86GV\bTڥ]7ס~-"|"|ubAcͩG z2a]{?"sdRoe e)zށށ%Rnt`b(䊊J9 a'* ^/mV'Bsw,.QqR`nBى"!Vt`%zW"#f T"}8$ {^#'_B^^^ { C3W AKJSꭓx} | J9x{-`}-@C-4bw~%e!|R-đkLgīo'ރI["3T_ZChB1҄ Hp0b$b+Al1~gzFYJ%leʩOdp]aؠ!K%XF KYJ--TXF"R,e/0CP= 1maG `wԞ{PLZE/CLs`K1#0. ːp^fŕ!MiF"p !QIf@F[a )>P_Ȧ6k-? a8c6Gf0bj^厒5U|qDĽ1oU!_ bЋ)G ɝ\/)տRpMtFm@;&Ymz['K~X:6ߊ߀aX<4>}!| o7lBȻŅ!C1dxœ-(jVGV *El¤a"Kɝ~y14S_smuPni4HG^O=&e~)K9qtߏye @HyD?<4{{υ!A1Bcn hfhEl˖U~yвԪ e! Ú`>H&<-4iCiĞEo~AOC?crwT" Nؐz 8`|-`|eo qכ0vӈìnC"M2 p%›akYaNo06e|*]>*5|y¼4(5G<@OꃸxSFUw/)6 8fmIv0Q> rH@RsAV/ wJ $e~8&t m@C.!j P< h' _iS ۛF4 4?c!.* l)Mm$(&Q2y`q~ ME3/Xn=%3k/}_ɴB1BumދEɁbhCEq"׋ӆ)O_& dڼ'hC{qIBALP{!w2pWvRͥϗnqA;"6_XIpD?1{laXe<~}12HM@i`xyoDre?XF-HH ׎kx :"|so >tҖ%Lڒw~VA1i!˹ {Q#E{ BPFWx?g f-WτMNPD Ѱy<(jGkgŻnC<,뎑дX.`!/3\aBA3d` E{l%l2ʎM:dbӷHvl*T3)ܯt:,,Y $eȉP}<>Y9$"┤ _ _[kEDMTHBdP1{=`9楸ۜ9)FYiѾAt%-p6%ZϔMf~&mN~l4S̘EWrے0ɰ˂s<@ ~ -u{8㎲`A8N.q"-ǥgKҵ 笭 vrL, ͟vf?`j/)&Qƅ'} c su1`XxV,J쾕Q]*9e[S!`kToZJ*sCIʨJcM4*˅6 XeworIx4Dl"iOBo!V1}ߛUqȆ vb7$R)`# e;}3Z*lae!4Ļ v) XSʥdۧt@pV`l3̃/i>`6 WG7|_ |1SQ# Dd$ 00  # A2QN}\HJwz*-x`!%N}\HJwz*G p x[ tUR $@EHHa DհMPԒ,bD6(b hz=zf\Fm8ۨݙ׫zB>zRJB^HЃ__Dm,q4B4"~4ۗMdehM%TP4pRT߀_$]5, _jNMSC th|:ɖ<&֙8[| *ћk@JVXcK QjdE*lkf=p5͌cj~rjF[3!#kbf⍎5ژ ^ڹu8e#CͲU3e#C+`[S,&vcsllsϾD1G}.^\؏p }.?W⺜.o]٧5w>3}D\3gpyZC]3.E5h]*peA5udc[vc̈́߸50^EJyu fK@n2.kܫueqMeMRh 0 ep1 izs]9q6p5=f|hgAȞb sl\sޛJ[WA;Zo+؋l { v@ߋq7bXUкwk /amOHsP'VW5n+}̀6-dV*\H{lJHb-g=lj}l#D!  НbֱC>>{ !daQ+bq~~[lIxמYehS3Ze52=^Żm- }q+ęlkr.V--v{h]kލY;԰NBgViv844\p֕LrǨVKd&g~iKpoJꉅgjyUݙ[SVo|^7$5DZ)^9^ {mq|/9нs Jgy/Yo(!]x'.N<ӷCv;/mqvn[Sd-4^Ul c@Q_K%\Gy p*~l[yҲcG44-!iLQ.!$uI AΣD-gNI'(I` bj |Aqč<`=`'un؜Y}=|CJ( Z*2O SBdӭ!3)3e@M35DK$Ws!J(b-CJ%j|5dQDC#PT"V>.=*颼(Q")RwciEI"Ir|08c8Zv8HQRqD "gh}x !U'4y 8 ƀG2v@Ɛ`ԅ'y5TIHxchkvՓ+"IdTdpjtEei("&TTT0aPx_s TKGL^PuPOQ rN=)i |qS- K b .h)?>9Aؼ>{E%Co"zr)+oNRz?D4w i$e_Dħ >qn59(Tu#1 #92NHt w9r7V$O|&j̛y.H;oӅJf+j.8x1u63g"~.j#{Y9;ߝɞS[ {;Q6$;* sjS)FoJZ,1zreH)r=Q#D1!mG9ac;UXZQuɓzAmTz+MDYY6Ռ݂Z7!~!.XlEuȳe! w"وw!=d>&`dP P]U798e9p#,/:{"/lS;؋G<>' {oGہfUFsۥv+=JoR)R-G009#{=yv>w"CAمk-+Y@많":"LEӏ+t,`{ǕzB=ړXPb`G\B({Lѧ]TH|#.sB(ϥHdS_ԣ Ȧ~2B[NEy|HkNrF0_Qb&whG|7 q9ȋ'$-2{I׎Ah@B6$i 6$@uz{A$۾vXȂ,t 䲡r]HA/1t*BAwhG$ڱ2 H0C!\9;}-\}]2[Cp*o Ic{3M~+Ǔ,|.++HMƸG"ܼw871.:H~Fq@h|9"kfD6 Zȝі(OES 1X݆[jHX׼\.fJݠVCRo_Q!]ʟaKr@|#@Uu HºBM$θ69Y]CouRaEtjy+M.dSqKZ#TX~\ϕ>)Op]pFb2؀~?HB[.HF T;sc#Ɇ-/m֖5v!K0\G-k\mܸ)쇖+*qgmyŒrUb2 KDW 0ډprtô#&٠6hw6ڑfue;\sZjBY*2[èk^EX#:_ *T8φga鉵NGI=; MvEi4|, F4)X(K- w gnƩA=}ʮCuab*ڐpiSAՊnvyMTkB_9Hb$ԗ 3ݹfW ykXC.VB5ZnK̩.UC[ڬmwsߕ{q+=d0!9ɷn?@~]LЃ.}KqGBY(Zk(vĹ-5یS-d:k8 vBV!~XlFnyMH0o,QFZNwc&$ zaYc1C[ta4!k":j(qhFz=< GnD,Bt j ^ l"^G9J.%67N#x/&wWV-$(Y $-zxJQс(oпRtU<kB}KMQ1R&M|vvHr/UrS d+vNjdjW l"Ce.pƵ Xŷh/^g:G3Ap9B3U< 3ǮK>sB|V*zv 3Lw`oXߢ?iSummaryInformation(Q>HDocumentSummaryInformation8HCompObjPj     The authors present an efficient stereoselective synthesis of an important intermediate in carbapenem synthesis. Both text and experimentals are clear, and useful.eTheCathy TingleyreathNormali David Y. Ginre4viMicrosoft Word 9.0t@G@<|I@jou@7 J՜.+,0 hp  University of Illinois&[  The authors present an efficient stereoselective synthesis of an important intermediate in carbapenem synthesis. Both text and experimentals are clear, and useful. Title i4@4 NormalCJ_HmH sH tH 66 Heading 1$$@&a$5<@< Heading 2$$@&a$ 5:\<A@< Default Paragraph FontN>@N Title $L]^L`a$5OJQJtH uHCH Body Text Indentd85CJtH u,@, Header  !, @", Footer  !&)@1& Page Number Z      Zopqstkln  *+ !!!2!3!$$$%%?)@)A)d)e)8-000!1"16;;;;;B1I2I3IVIWIMLPPPPPU~ZZZZZZZZ00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000@0@@0@0 +8FFFI:%?*/5|<rENNV]els*tCGHIKLMNOQRSTUV%A t*tDFJPW)tE &(!.!0!$%%A)`)b)011;;;3IRITIPPPZ:::::::::::::::+249@BI!!,2$7(&2$0[ ֊2`-2$T4v'ylK*2$qVz^\8'2$ʶcwTby*+2$KBM}&pL2$b0- {t02$xfcߎA@'2$ilTN252$g\XXeXL/<j2$Yf8,d6<$2$ V0s@ +2$K]/8ͨʣJG+2$6 5TTX29]&2$U!AT߸+2$y 9/(Nw82 @(2$)QQZ6@0(  B S  ?Z+.6=?Fy}2<^c'8X_ *4AEF H  E I       M O 8=ko`b(1\ew{(z"8:gi\d02;@fk!EHsvLN  !25FIZ]qvOR}68!#RUfiz} 7!9!=!?!S!X!!!%"'"D"F"O"Q"w"y"""""$#&#U#X#i#l#}####$$% %&%(%%%%%%%A&C&&&&&&& ))k)m)* ***,*5*7*{*}***++++.+?+B+S+V+s+v+x+{+++++++- ->-@-----..D.F......./ /9/>m>p>>>>>??/?1???????BBBB CC$C'C>CAChCjCCCDDODRDDDDDDD*E-E^EaEEEEEEF F F2F4FnFpFFFHI]I_IIIIIIIJJ5J8JJJJJbKdKKKL!LSLULLLLLLLLLMMMM=M?McMfMMMMMNNPNbNeNNNNN/O1OiOkOQPVPPPPQQQ0Q3QIQLQUQXQQQQQQQRRRRSS7S:S\S^SSSSSSSTT,T.TTTUUUUAVDVYV\VrVuVVVVVVVVV6W8W{W}WWWWW XX5X7XXXXXXXYYWYYYIZNZZZZZZZZZhj ( rt <kmot%%./11ZZZZ33333333333333333Jannine Haberman;C:\My Documents\characterization\Supporting information.docJannine Haberman;C:\My Documents\characterization\Supporting information.docJannine Haberman;C:\My Documents\characterization\Supporting information.docJannine Haberman;C:\My Documents\characterization\Supporting information.docJannine Haberman;C:\My Documents\characterization\Supporting information.docJannine Haberman;C:\My Documents\characterization\Supporting information.doc David Y. Gin?D:\uiuc\2000\publications\sialyl gly\Supporting information.doc David Y. GinDD:\uiuc\2001\publications\sialyl gly\JACS\Supporting information.doc David Y. GinHD:\uiuc\2001\publications\sialyl gly\Org Lett\Supporting information.doc David Y. GinHD:\uiuc\2001\publications\sialyl gly\Org Lett\Supporting information.docZZZ@HP LaserJet 4000 Series PCLLPT1:winspoolHP LaserJet 4000 Series PCLHP LaserJet 4000 Series PCL0C odXXLetter DINU"07խ HP LaserJet 4000 Series PCL0C odXXLetter DINU"07խ ..xt.  ():-:.:0:167;<BCYIYJOLOMPQUVZ`` @` `@``(@```4@``` `D@`6`p@`<`|@`@`@`H`@`N`@`V`@`^`@`b`@`h`@`n`@UnknownGz Times New Roman5Symbol3& z Arial?Wingdings 33z Times"qhQfk|SAKf J&!20[2 The authors present an efficient stereoselective synthesis of an important intermediate in carbapenem synthesis. Both text and experimentals are clear, and useful. Cathy Tingley David Y. Gin  FMicrosoft Word Document MSWordDocWord.Document.89q